MYO6 [The Human Chemical-Genetic Interaction Map Project]

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======= MYO6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO6
  * **<color #00a2e8>Official Name</color>**: myosin VI
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4646|4646]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UM54|Q9UM54]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|minus-end directed microfilament motor activity|
|unconventional myosin complex|
|RNA polymerase II, holoenzyme|
|clathrin-coated endocytic vesicle|
|filamentous actin|
|ADP binding|
|motor activity|
|clathrin-coated vesicle membrane|
|clathrin-coated pit|
|endocytic vesicle|
|microvillus|
|apical part of cell|
|filopodium|
|DNA damage response, signal transduction by p53 class mediator|
|actin filament|
|ruffle|
|ruffle membrane|
|signal transduction in response to DNA damage|
|actin filament-based movement|
|signal transduction by p53 class mediator|
|cell cortex|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|calmodulin binding|
|actin filament binding|
|nuclear membrane|
|cytoplasmic vesicle|
|actin binding|
|lysosomal membrane|
|endocytosis|
|actin filament-based process|
|import into cell|
|perinuclear region of cytoplasm|
|cellular response to DNA damage stimulus|
|regulation of secretion|
|sensory perception|
|Golgi apparatus|
|intracellular protein transport|
|response to drug|
|positive regulation of transcription by RNA polymerase II|
|nervous system process|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO6 Expression in NALM6 Cells: 2.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>