MYO9A [The Human Chemical-Genetic Interaction Map Project]

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======= MYO9A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO9A
  * **<color #00a2e8>Official Name</color>**: myosin IXA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4649|4649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/B2RTY4|B2RTY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO9A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO9A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604875|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RA|
|RhoGAP|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|unconventional myosin complex|
|regulation of neuron projection arborization|
|establishment of epithelial cell apical/basal polarity|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|axonal growth cone|
|establishment of epithelial cell polarity|
|morphogenesis of a polarized epithelium|
|motor activity|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment of cell polarity|
|cell junction assembly|
|establishment or maintenance of cell polarity|
|cell junction organization|
|visual perception|
|sensory perception of light stimulus|
|synapse|
|actin binding|
|GTPase activator activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|morphogenesis of an epithelium|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell junction|
|tissue morphogenesis|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|sensory perception|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|regulation of hydrolase activity|
|nervous system process|
|positive regulation of catalytic activity|
|ATP binding|
|generation of neurons|
|neurogenesis|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.22|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.84|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.85|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.23|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.36|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.64|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|3.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO9A Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>