NAA25 [The Human Chemical-Genetic Interaction Map Project]

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======= NAA25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA25
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 25, NatB auxiliary subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80018|80018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14CX7|Q14CX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612755|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. {ECO:0000269|PubMed:18570629}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NatB MDM20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NatB complex|
|N-terminal peptidyl-methionine acetylation|
|peptide alpha-N-acetyltransferase activity|
|peptidyl-methionine modification|
|N-terminal protein amino acid acetylation|
|N-terminal protein amino acid modification|
|protein acetylation|
|protein acylation|
|protein maturation|
|peptidyl-amino acid modification|
|Golgi apparatus|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.9|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.86|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.75|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.7|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 102/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|7/28|
|bone|7/26|
|breast|3/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|3/20|
|lung|9/75|
|lymphocyte|5/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|4/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 98
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA25 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>