NAA35 [The Human Chemical-Genetic Interaction Map Project]

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======= NAA35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA35
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 35, NatC auxiliary subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60560|60560]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VZE5|Q5VZE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619438|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. {ECO:0000269|PubMed:19398576}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mak10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NatC complex|
|smooth muscle cell proliferation|
|N-terminal peptidyl-methionine acetylation|
|peptide alpha-N-acetyltransferase activity|
|peptidyl-methionine modification|
|N-terminal protein amino acid acetylation|
|muscle cell proliferation|
|N-terminal protein amino acid modification|
|polysome|
|protein acetylation|
|protein acylation|
|protein maturation|
|cell population proliferation|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.7|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lsmd1|LSMD1]]|0.498|
|[[:human genes:h:hars|HARS]]|0.414|
|[[:human genes:t:tle4|TLE4]]|0.411|
|[[:human genes:b:btaf1|BTAF1]]|0.409|
|[[:human genes:s:smarcd1|SMARCD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 158/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|4/28|
|bone|2/26|
|breast|10/33|
|central nervous system|4/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|4/21|
|liver|3/20|
|lung|28/75|
|lymphocyte|4/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|5/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA35 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>