NAF1 [The Human Chemical-Genetic Interaction Map Project]

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======= NAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AF1
  * **<color #00a2e8>Official Name</color>**: nuclear assembly factor 1 ribonucleoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92345|92345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HR8|Q96HR8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617868|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gar1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|box H/ACA snoRNP assembly|
|snoRNA guided rRNA pseudouridine synthesis|
|telomerase RNA stabilization|
|telomerase holoenzyme complex assembly|
|rRNA pseudouridine synthesis|
|small nucleolar ribonucleoprotein complex|
|small nucleolar ribonucleoprotein complex assembly|
|positive regulation of telomerase RNA localization to Cajal body|
|pseudouridine synthesis|
|regulation of telomerase RNA localization to Cajal body|
|telomerase RNA binding|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|rRNA modification|
|positive regulation of telomere maintenance via telomere lengthening|
|RNA stabilization|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|negative regulation of RNA catabolic process|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|regulation of telomere maintenance|
|regulation of DNA biosynthetic process|
|RNA modification|
|positive regulation of chromosome organization|
|regulation of RNA stability|
|positive regulation of DNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|negative regulation of cellular catabolic process|
|ribosome biogenesis|
|negative regulation of catabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of transferase activity|
|regulation of catabolic process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|protein-containing complex assembly|
|RNA metabolic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.29|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.06|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:adsl|ADSL]]|0.504|
|[[:human genes:z:zrsr2|ZRSR2]]|0.476|
|[[:human genes:r:rpp21|RPP21]]|0.466|
|[[:human genes:r:rnmt|RNMT]]|0.458|
|[[:human genes:t:thg1l|THG1L]]|0.452|
|[[:human genes:t:txnl4b|TXNL4B]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.431|
|[[:human genes:u:utp23|UTP23]]|0.427|
|[[:human genes:g:gmppb|GMPPB]]|0.426|
|[[:human genes:h:hspd1|HSPD1]]|0.415|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:e:exoc4|EXOC4]]|0.408|
|[[:human genes:y:yars|YARS]]|0.408|
|[[:human genes:a:atp5o|ATP5O]]|0.406|
|[[:human genes:r:rpe|RPE]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3913
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAF1 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>