NANOS1 [The Human Chemical-Genetic Interaction Map Project]

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======= NANOS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ANOS1
  * **<color #00a2e8>Official Name</color>**: nanos C2HC-type zinc finger 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340719|340719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WY41|Q8WY41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NANOS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NANOS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608226|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-nanos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar neuron development|
|translation repressor activity|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of mRNA catabolic process|
|positive regulation of mRNA metabolic process|
|central nervous system neuron development|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|cerebellum development|
|metencephalon development|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|hindbrain development|
|ameboidal-type cell migration|
|central nervous system neuron differentiation|
|tissue homeostasis|
|regulation of mRNA catabolic process|
|multicellular organismal homeostasis|
|regulation of mRNA metabolic process|
|anatomical structure homeostasis|
|regulation of translation|
|positive regulation of cellular catabolic process|
|regulation of cellular amide metabolic process|
|regulation of cell growth|
|positive regulation of catabolic process|
|posttranscriptional regulation of gene expression|
|regulation of growth|
|perinuclear region of cytoplasm|
|brain development|
|head development|
|neuron development|
|regulation of cellular catabolic process|
|zinc ion binding|
|cell migration|
|central nervous system development|
|regulation of catabolic process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|locomotion|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|neurogenesis|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.1|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.82|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11032
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NANOS1 Expression in NALM6 Cells: 1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>