NCAPG [The Human Chemical-Genetic Interaction Map Project]

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======= NCAPG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAPG
  * **<color #00a2e8>Official Name</color>**: non-SMC condensin I complex subunit G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64151|64151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BPX3|Q9BPX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAPG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAPG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cnd3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensin complex|
|condensed chromosome, centromeric region|
|mitotic chromosome condensation|
|condensed chromosome|
|chromosome condensation|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|DNA packaging|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cell cycle|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.91|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.84|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.545|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.47|
|[[:human genes:p:psma7|PSMA7]]|0.47|
|[[:human genes:p:psmb4|PSMB4]]|0.465|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.455|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.454|
|[[:human genes:a:aamp|AAMP]]|0.451|
|[[:human genes:n:nup160|NUP160]]|0.44|
|[[:human genes:r:rps20|RPS20]]|0.438|
|[[:human genes:f:fam86b2|FAM86B2]]|0.438|
|[[:human genes:p:polr2j3|POLR2J3]]|0.437|
|[[:human genes:c:cdc73|CDC73]]|0.427|
|[[:human genes:p:polr2f|POLR2F]]|0.424|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.42|
|[[:human genes:t:tceb3c|TCEB3C]]|0.419|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:z:znf219|ZNF219]]|0.418|
|[[:human genes:p:pola2|POLA2]]|0.417|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.417|
|[[:human genes:c:chd4|CHD4]]|0.416|
|[[:human genes:s:slc6a17|SLC6A17]]|0.41|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.41|
|[[:human genes:r:rps5|RPS5]]|0.409|
|[[:human genes:s:sart1|SART1]]|0.409|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.408|
|[[:human genes:v:vasn|VASN]]|0.406|
|[[:human genes:r:rpl6|RPL6]]|0.405|
|[[:human genes:r:rps7|RPS7]]|0.401|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 723/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 693
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAPG Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>