NCF1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCF1
  * **<color #00a2e8>Official Name</color>**: neutrophil cytosolic factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653361|653361]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14598|P14598]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|PX|
|SH3 1|
|p47 phox C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagolysosome|
|positive regulation of epidermal growth factor-activated receptor activity|
|superoxide-generating NADPH oxidase activator activity|
|superoxide-generating NADPH oxidase activity|
|NADPH oxidase complex|
|superoxide anion generation|
|respiratory burst|
|positive regulation of p38MAPK cascade|
|regulation of epidermal growth factor-activated receptor activity|
|phosphatidylinositol-3,4-bisphosphate binding|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of ERBB signaling pathway|
|positive regulation of signaling receptor activity|
|cellular response to cadmium ion|
|superoxide metabolic process|
|regulation of p38MAPK cascade|
|cellular defense response|
|positive regulation of protein tyrosine kinase activity|
|rough endoplasmic reticulum|
|response to cadmium ion|
|extrinsic component of membrane|
|vascular endothelial growth factor receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|cell redox homeostasis|
|electron transfer activity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|phosphatidylinositol binding|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|reactive oxygen species metabolic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|SH3 domain binding|
|cellular response to reactive oxygen species|
|positive regulation of JNK cascade|
|protein targeting to membrane|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of signaling receptor activity|
|antigen processing and presentation of exogenous peptide antigen|
|electron transport chain|
|antigen processing and presentation of exogenous antigen|
|regulation of JNK cascade|
|antigen processing and presentation of peptide antigen|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to metal ion|
|response to reactive oxygen species|
|antigen processing and presentation|
|cellular response to inorganic substance|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|regulation of peptidyl-tyrosine phosphorylation|
|establishment of protein localization to membrane|
|protein targeting|
|response to metal ion|
|neuronal cell body|
|response to oxidative stress|
|dendrite|
|generation of precursor metabolites and energy|
|protein localization to membrane|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|innate immune response|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular homeostasis|
|apoptotic process|
|defense response to other organism|
|oxidation-reduction process|
|regulation of transferase activity|
|Golgi apparatus|
|intracellular protein transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell death|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4901
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCF1 Expression in NALM6 Cells: 1.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>