NCK2 [The Human Chemical-Genetic Interaction Map Project]

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======= NCK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCK2
  * **<color #00a2e8>Official Name</color>**: NCK adaptor protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8440|8440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43639|O43639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH3 1|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of translation in response to endoplasmic reticulum stress|
|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|
|negative regulation of PERK-mediated unfolded protein response|
|positive regulation of translation in response to stress|
|regulation of translation in response to endoplasmic reticulum stress|
|signal complex assembly|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of PERK-mediated unfolded protein response|
|negative regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|cytoskeletal adaptor activity|
|immunological synapse formation|
|regulation of translation in response to stress|
|receptor signaling complex adaptor activity|
|regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of peptidyl-serine phosphorylation|
|regulation of epidermal growth factor-activated receptor activity|
|dendritic spine development|
|vesicle membrane|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|lamellipodium assembly|
|positive regulation of response to endoplasmic reticulum stress|
|phosphotyrosine residue binding|
|lamellipodium organization|
|negative regulation of response to endoplasmic reticulum stress|
|epidermal growth factor receptor signaling pathway|
|SH3/SH2 adaptor activity|
|positive regulation of intrinsic apoptotic signaling pathway|
|scaffold protein binding|
|vascular endothelial growth factor receptor signaling pathway|
|cell-cell recognition|
|ERBB signaling pathway|
|regulation of translational initiation|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of response to endoplasmic reticulum stress|
|ephrin receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|positive regulation of actin filament polymerization|
|positive regulation of T cell proliferation|
|dendrite development|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|positive regulation of translation|
|positive regulation of protein polymerization|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of cellular amide metabolic process|
|regulation of T cell proliferation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of actin filament polymerization|
|regulation of signaling receptor activity|
|positive regulation of apoptotic signaling pathway|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cytoskeleton organization|
|regulation of leukocyte proliferation|
|regulation of protein polymerization|
|T cell activation|
|cell recognition|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|positive regulation of cell-cell adhesion|
|response to endoplasmic reticulum stress|
|regulation of actin filament organization|
|protein-containing complex binding|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of translation|
|positive regulation of lymphocyte activation|
|regulation of cellular component size|
|lymphocyte activation|
|regulation of actin filament-based process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of protein kinase activity|
|neuron development|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|endoplasmic reticulum|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cell activation|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCK2 Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>