NCOA6 [The Human Chemical-Genetic Interaction Map Project]

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======= NCOA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCOA6
  * **<color #00a2e8>Official Name</color>**: nuclear receptor coactivator 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23054|23054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14686|Q14686]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCOA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCOA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605299|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucocorticoid receptor signaling pathway|
|corticosteroid receptor signaling pathway|
|retinoid X receptor binding|
|intracellular estrogen receptor signaling pathway|
|thyroid hormone receptor binding|
|histone methyltransferase complex|
|estrogen receptor binding|
|nuclear receptor transcription coactivator activity|
|intracellular steroid hormone receptor signaling pathway|
|steroid hormone mediated signaling pathway|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|transcription factor complex|
|DNA replication|
|DNA-templated transcription, initiation|
|myeloid cell differentiation|
|DNA recombination|
|transcription coactivator activity|
|response to steroid hormone|
|enzyme binding|
|chromatin binding|
|regulation of lipid metabolic process|
|DNA repair|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|hemopoiesis|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|intracellular membrane-bounded organelle|
|brain development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|head development|
|response to lipid|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|central nervous system development|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.71|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.75|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.94|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15709
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCOA6 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>