NCS1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCS1
  * **<color #00a2e8>Official Name</color>**: neuronal calcium sensor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23413|23413]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62166|P62166]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603315|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|
|dense core granule|
|presynaptic cytosol|
|regulation of presynaptic cytosolic calcium ion concentration|
|postsynaptic cytosol|
|calyx of Held|
|neuron cellular homeostasis|
|voltage-gated calcium channel activity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|regulation of synaptic vesicle exocytosis|
|positive regulation of exocytosis|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|magnesium ion binding|
|regulation of exocytosis|
|calcium ion transport|
|postsynaptic density|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|dendrite|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|cell junction|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of transport|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|intracellular signal transduction|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15610
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCS1 Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>