NDNL2 [The Human Chemical-Genetic Interaction Map Project]

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======= NDNL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSMCE3
  * **<color #00a2e8>Official Name</color>**: NSE3 homolog, SMC5-SMC6 complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56160|56160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MG7|Q96MG7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDNL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDNL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAGE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Smc5-Smc6 complex|
|cellular response to hydroxyurea|
|response to hydroxyurea|
|response to antimetabolite|
|chromosome, telomeric region|
|cellular response to UV|
|response to antineoplastic agent|
|cellular response to light stimulus|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|response to UV|
|protein dimerization activity|
|cellular response to radiation|
|regulation of protein ubiquitination|
|cellular response to inorganic substance|
|DNA recombination|
|regulation of protein modification by small protein conjugation or removal|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to drug|
|response to radiation|
|DNA repair|
|response to inorganic substance|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.35|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.99|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 410/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|19/28|
|bone|17/26|
|breast|19/33|
|central nervous system|32/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|10/21|
|liver|8/20|
|lung|35/75|
|lymphocyte|6/16|
|ovary|16/26|
|pancreas|12/24|
|peripheral nervous system|5/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|18/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 697
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDNL2 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>