NDUFA10 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA10
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4705|4705]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95299|O95299]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dNK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.91|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.88|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.73|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.02|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.23|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.28|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.31|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.31|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb5|NDUFB5]]|0.598|
|[[:human genes:n:ndufa11|NDUFA11]]|0.591|
|[[:human genes:n:ndufa1|NDUFA1]]|0.59|
|[[:human genes:n:ndufb11|NDUFB11]]|0.589|
|[[:human genes:n:ndufs2|NDUFS2]]|0.586|
|[[:human genes:n:ndufb6|NDUFB6]]|0.585|
|[[:human genes:g:grsf1|GRSF1]]|0.582|
|[[:human genes:n:ndufa2|NDUFA2]]|0.574|
|[[:human genes:a:acad9|ACAD9]]|0.568|
|[[:human genes:m:mto1|MTO1]]|0.567|
|[[:human genes:e:ecsit|ECSIT]]|0.562|
|[[:human genes:n:ndufb9|NDUFB9]]|0.562|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.556|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.55|
|[[:human genes:n:ndufa3|NDUFA3]]|0.544|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.521|
|[[:human genes:n:nubpl|NUBPL]]|0.516|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.515|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.506|
|[[:human genes:n:ndufc2|NDUFC2]]|0.506|
|[[:human genes:n:ndufs3|NDUFS3]]|0.506|
|[[:human genes:n:ndufa8|NDUFA8]]|0.501|
|[[:human genes:n:ndufb4|NDUFB4]]|0.5|
|[[:human genes:c:c17orf89|C17orf89]]|0.497|
|[[:human genes:n:ndufb10|NDUFB10]]|0.496|
|[[:human genes:g:gfm1|GFM1]]|0.494|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.493|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.492|
|[[:human genes:y:yars2|YARS2]]|0.488|
|[[:human genes:n:ndufb7|NDUFB7]]|0.486|
|[[:human genes:r:rpusd3|RPUSD3]]|0.484|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.482|
|[[:human genes:n:ndufs7|NDUFS7]]|0.48|
|[[:human genes:n:ndufb2|NDUFB2]]|0.476|
|[[:human genes:p:polg|POLG]]|0.475|
|[[:human genes:n:ndufs5|NDUFS5]]|0.471|
|[[:human genes:r:rbfa|RBFA]]|0.47|
|[[:human genes:m:mrps21|MRPS21]]|0.47|
|[[:human genes:n:ndufc1|NDUFC1]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.469|
|[[:human genes:m:malsu1|MALSU1]]|0.463|
|[[:human genes:n:ndufa13|NDUFA13]]|0.462|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.461|
|[[:human genes:m:mrpl43|MRPL43]]|0.46|
|[[:human genes:n:nfu1|NFU1]]|0.46|
|[[:human genes:n:ndufs1|NDUFS1]]|0.46|
|[[:human genes:m:mrpl45|MRPL45]]|0.459|
|[[:human genes:f:fastkd2|FASTKD2]]|0.459|
|[[:human genes:m:mettl17|METTL17]]|0.457|
|[[:human genes:a:atp5sl|ATP5SL]]|0.456|
|[[:human genes:p:polg2|POLG2]]|0.455|
|[[:human genes:l:lars2|LARS2]]|0.45|
|[[:human genes:m:mterfd1|MTERFD1]]|0.448|
|[[:human genes:e:ears2|EARS2]]|0.448|
|[[:human genes:n:ndufv2|NDUFV2]]|0.448|
|[[:human genes:g:gfm2|GFM2]]|0.446|
|[[:human genes:t:tmem261|TMEM261]]|0.443|
|[[:human genes:m:mrps5|MRPS5]]|0.443|
|[[:human genes:m:mcat|MCAT]]|0.443|
|[[:human genes:f:foxred1|FOXRED1]]|0.441|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.438|
|[[:human genes:t:tars2|TARS2]]|0.438|
|[[:human genes:s:sco2|SCO2]]|0.437|
|[[:human genes:t:tfb1m|TFB1M]]|0.435|
|[[:human genes:n:ndufs8|NDUFS8]]|0.434|
|[[:human genes:m:mrps33|MRPS33]]|0.433|
|[[:human genes:e:eral1|ERAL1]]|0.431|
|[[:human genes:i:iba57|IBA57]]|0.429|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.429|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.429|
|[[:human genes:m:mars2|MARS2]]|0.428|
|[[:human genes:f:ftsj2|FTSJ2]]|0.427|
|[[:human genes:n:nars2|NARS2]]|0.426|
|[[:human genes:m:mrpl15|MRPL15]]|0.426|
|[[:human genes:m:mrpl21|MRPL21]]|0.426|
|[[:human genes:a:aars2|AARS2]]|0.425|
|[[:human genes:q:qrsl1|QRSL1]]|0.424|
|[[:human genes:g:gatc|GATC]]|0.423|
|[[:human genes:g:glrx5|GLRX5]]|0.422|
|[[:human genes:m:mtif2|MTIF2]]|0.422|
|[[:human genes:c:coq7|COQ7]]|0.422|
|[[:human genes:r:rars2|RARS2]]|0.422|
|[[:human genes:m:mrps16|MRPS16]]|0.422|
|[[:human genes:t:tufm|TUFM]]|0.422|
|[[:human genes:c:cox11|COX11]]|0.42|
|[[:human genes:c:cox16|COX16]]|0.419|
|[[:human genes:s:selrc1|SELRC1]]|0.419|
|[[:human genes:m:mrps6|MRPS6]]|0.419|
|[[:human genes:m:mrps26|MRPS26]]|0.418|
|[[:human genes:c:c12orf65|C12orf65]]|0.417|
|[[:human genes:o:oma1|OMA1]]|0.413|
|[[:human genes:c:cox20|COX20]]|0.413|
|[[:human genes:p:pet112|PET112]]|0.411|
|[[:human genes:p:pet117|PET117]]|0.411|
|[[:human genes:m:mrpl53|MRPL53]]|0.408|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.407|
|[[:human genes:n:ndufa6|NDUFA6]]|0.406|
|[[:human genes:h:hars2|HARS2]]|0.403|
|[[:human genes:s:sfxn4|SFXN4]]|0.403|
|[[:human genes:p:pars2|PARS2]]|0.402|
|[[:human genes:c:c1qbp|C1QBP]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2013
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA10 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>