NDUFB1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4707|4707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75438|O75438]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NADH oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|nuclear speck|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.85|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrp63|MRP63]]|0.474|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.47|
|[[:human genes:m:mrpl21|MRPL21]]|0.467|
|[[:human genes:c:c17orf89|C17orf89]]|0.465|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.461|
|[[:human genes:y:yars2|YARS2]]|0.459|
|[[:human genes:n:ndufb11|NDUFB11]]|0.457|
|[[:human genes:c:c12orf65|C12orf65]]|0.455|
|[[:human genes:a:atp5h|ATP5H]]|0.445|
|[[:human genes:s:ssb|SSB]]|0.445|
|[[:human genes:t:tars2|TARS2]]|0.44|
|[[:human genes:m:mrpl23|MRPL23]]|0.438|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.438|
|[[:human genes:d:dars2|DARS2]]|0.436|
|[[:human genes:m:mrps24|MRPS24]]|0.434|
|[[:human genes:n:ndufa1|NDUFA1]]|0.433|
|[[:human genes:m:mrpl53|MRPL53]]|0.432|
|[[:human genes:a:atp5a1|ATP5A1]]|0.431|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:b:bcs1l|BCS1L]]|0.428|
|[[:human genes:p:pdss1|PDSS1]]|0.427|
|[[:human genes:a:alg1|ALG1]]|0.425|
|[[:human genes:m:mrps18a|MRPS18A]]|0.425|
|[[:human genes:v:vars2|VARS2]]|0.424|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.423|
|[[:human genes:e:eif3f|EIF3F]]|0.423|
|[[:human genes:s:selrc1|SELRC1]]|0.422|
|[[:human genes:a:atp5d|ATP5D]]|0.421|
|[[:human genes:p:ppa2|PPA2]]|0.418|
|[[:human genes:p:pgm3|PGM3]]|0.418|
|[[:human genes:c:chchd4|CHCHD4]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.416|
|[[:human genes:c:cox5a|COX5A]]|0.416|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.415|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.415|
|[[:human genes:n:ndufa3|NDUFA3]]|0.413|
|[[:human genes:m:mrps34|MRPS34]]|0.411|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.41|
|[[:human genes:a:atp5o|ATP5O]]|0.409|
|[[:human genes:m:mrpl20|MRPL20]]|0.409|
|[[:human genes:u:uhrf1|UHRF1]]|0.408|
|[[:human genes:c:c10orf2|C10orf2]]|0.406|
|[[:human genes:n:ndufv1|NDUFV1]]|0.404|
|[[:human genes:r:rptor|RPTOR]]|0.404|
|[[:human genes:g:gfm2|GFM2]]|0.402|
|[[:human genes:s:sars2|SARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6871
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>