NDUFB3 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB3
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4709|4709]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43676|O43676]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603839|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.64|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-2.52|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.33|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-2.15|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.06|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.01|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.98|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.91|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.91|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.9|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.84|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.77|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.72|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.71|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.76|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.81|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.89|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.94|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.98|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.04|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps14|MRPS14]]|0.534|
|[[:human genes:p:pdss1|PDSS1]]|0.53|
|[[:human genes:n:ndufa3|NDUFA3]]|0.527|
|[[:human genes:c:c17orf89|C17orf89]]|0.522|
|[[:human genes:m:mrpl21|MRPL21]]|0.52|
|[[:human genes:n:ndufb5|NDUFB5]]|0.518|
|[[:human genes:m:mrpl15|MRPL15]]|0.516|
|[[:human genes:n:ndufc2|NDUFC2]]|0.511|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.509|
|[[:human genes:g:gfm1|GFM1]]|0.508|
|[[:human genes:t:tefm|TEFM]]|0.506|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.503|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.5|
|[[:human genes:b:bcs1l|BCS1L]]|0.495|
|[[:human genes:m:mrps21|MRPS21]]|0.494|
|[[:human genes:c:c10orf2|C10orf2]]|0.491|
|[[:human genes:c:coq2|COQ2]]|0.489|
|[[:human genes:t:tufm|TUFM]]|0.487|
|[[:human genes:m:mrpl47|MRPL47]]|0.483|
|[[:human genes:n:ndufs2|NDUFS2]]|0.482|
|[[:human genes:y:yars2|YARS2]]|0.481|
|[[:human genes:n:ndufb11|NDUFB11]]|0.48|
|[[:human genes:r:rpusd4|RPUSD4]]|0.478|
|[[:human genes:n:ndufa5|NDUFA5]]|0.477|
|[[:human genes:n:ndufa2|NDUFA2]]|0.474|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.473|
|[[:human genes:s:slc25a26|SLC25A26]]|0.472|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.471|
|[[:human genes:n:ndufs7|NDUFS7]]|0.47|
|[[:human genes:n:ndufa1|NDUFA1]]|0.47|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.47|
|[[:human genes:a:atp5sl|ATP5SL]]|0.469|
|[[:human genes:e:elac2|ELAC2]]|0.467|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.466|
|[[:human genes:c:cox16|COX16]]|0.464|
|[[:human genes:n:ndufa11|NDUFA11]]|0.464|
|[[:human genes:c:c12orf65|C12orf65]]|0.461|
|[[:human genes:n:ndufb6|NDUFB6]]|0.459|
|[[:human genes:g:grsf1|GRSF1]]|0.459|
|[[:human genes:s:sars2|SARS2]]|0.456|
|[[:human genes:w:wbscr16|WBSCR16]]|0.456|
|[[:human genes:a:atp5d|ATP5D]]|0.456|
|[[:human genes:f:fastkd5|FASTKD5]]|0.451|
|[[:human genes:a:atp5c1|ATP5C1]]|0.451|
|[[:human genes:v:vars2|VARS2]]|0.45|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.447|
|[[:human genes:m:mrpl45|MRPL45]]|0.446|
|[[:human genes:c:coq7|COQ7]]|0.444|
|[[:human genes:q:qrsl1|QRSL1]]|0.444|
|[[:human genes:d:dars2|DARS2]]|0.444|
|[[:human genes:n:nars2|NARS2]]|0.443|
|[[:human genes:l:lars2|LARS2]]|0.443|
|[[:human genes:n:ndufb9|NDUFB9]]|0.442|
|[[:human genes:m:mrps9|MRPS9]]|0.442|
|[[:human genes:m:mrps17|MRPS17]]|0.442|
|[[:human genes:g:gfm2|GFM2]]|0.442|
|[[:human genes:m:mrpl20|MRPL20]]|0.441|
|[[:human genes:m:mrps34|MRPS34]]|0.44|
|[[:human genes:m:mrp63|MRP63]]|0.439|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.438|
|[[:human genes:a:atp5o|ATP5O]]|0.437|
|[[:human genes:m:mto1|MTO1]]|0.436|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.434|
|[[:human genes:n:ndufa8|NDUFA8]]|0.434|
|[[:human genes:m:mrps11|MRPS11]]|0.434|
|[[:human genes:p:polg|POLG]]|0.432|
|[[:human genes:a:atp5b|ATP5B]]|0.431|
|[[:human genes:s:sco2|SCO2]]|0.431|
|[[:human genes:m:mrpl23|MRPL23]]|0.43|
|[[:human genes:m:mrpl11|MRPL11]]|0.43|
|[[:human genes:m:mrps16|MRPS16]]|0.429|
|[[:human genes:m:mrps2|MRPS2]]|0.427|
|[[:human genes:m:mrpl3|MRPL3]]|0.426|
|[[:human genes:d:dhx30|DHX30]]|0.425|
|[[:human genes:g:gatc|GATC]]|0.424|
|[[:human genes:a:atp5a1|ATP5A1]]|0.424|
|[[:human genes:c:cox6c|COX6C]]|0.423|
|[[:human genes:r:rpusd3|RPUSD3]]|0.423|
|[[:human genes:f:fars2|FARS2]]|0.421|
|[[:human genes:n:ndufb2|NDUFB2]]|0.421|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.421|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.421|
|[[:human genes:u:uqcr10|UQCR10]]|0.421|
|[[:human genes:f:ftsj2|FTSJ2]]|0.42|
|[[:human genes:m:mrps5|MRPS5]]|0.419|
|[[:human genes:s:ssbp1|SSBP1]]|0.419|
|[[:human genes:m:mrpl53|MRPL53]]|0.418|
|[[:human genes:e:ecsit|ECSIT]]|0.417|
|[[:human genes:m:mrpl33|MRPL33]]|0.415|
|[[:human genes:m:mrpl12|MRPL12]]|0.415|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.413|
|[[:human genes:c:chchd1|CHCHD1]]|0.412|
|[[:human genes:d:dap3|DAP3]]|0.411|
|[[:human genes:m:mrps22|MRPS22]]|0.411|
|[[:human genes:t:tars2|TARS2]]|0.41|
|[[:human genes:m:mrps33|MRPS33]]|0.41|
|[[:human genes:m:mrps6|MRPS6]]|0.408|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.408|
|[[:human genes:m:mrpl43|MRPL43]]|0.407|
|[[:human genes:t:tomm22|TOMM22]]|0.406|
|[[:human genes:c:coq4|COQ4]]|0.406|
|[[:human genes:s:selrc1|SELRC1]]|0.404|
|[[:human genes:m:mrpl22|MRPL22]]|0.403|
|[[:human genes:m:mtg2|MTG2]]|0.402|
|[[:human genes:r:rars2|RARS2]]|0.402|
|[[:human genes:m:mrpl55|MRPL55]]|0.402|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.401|
|[[:human genes:a:atp5f1|ATP5F1]]|0.4|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 26/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|2/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2814
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB3 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>