NDUFB4 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB4
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4710|4710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95168|O95168]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|nuclear membrane|
|response to oxidative stress|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.8|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.9|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.15|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.638|
|[[:human genes:n:ndufb9|NDUFB9]]|0.609|
|[[:human genes:n:ndufc2|NDUFC2]]|0.592|
|[[:human genes:n:ndufs2|NDUFS2]]|0.584|
|[[:human genes:a:acad9|ACAD9]]|0.582|
|[[:human genes:g:grsf1|GRSF1]]|0.556|
|[[:human genes:n:ndufa11|NDUFA11]]|0.535|
|[[:human genes:n:ndufa13|NDUFA13]]|0.533|
|[[:human genes:n:ndufb11|NDUFB11]]|0.532|
|[[:human genes:n:nubpl|NUBPL]]|0.528|
|[[:human genes:m:mrpl45|MRPL45]]|0.525|
|[[:human genes:n:ndufb7|NDUFB7]]|0.525|
|[[:human genes:n:ndufa2|NDUFA2]]|0.524|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.516|
|[[:human genes:n:ndufs1|NDUFS1]]|0.514|
|[[:human genes:n:ndufa3|NDUFA3]]|0.512|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.511|
|[[:human genes:n:ndufa10|NDUFA10]]|0.5|
|[[:human genes:n:ndufv1|NDUFV1]]|0.498|
|[[:human genes:n:ndufs3|NDUFS3]]|0.49|
|[[:human genes:n:ndufc1|NDUFC1]]|0.49|
|[[:human genes:t:tfb1m|TFB1M]]|0.487|
|[[:human genes:m:mrpl13|MRPL13]]|0.481|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.48|
|[[:human genes:n:ndufb10|NDUFB10]]|0.48|
|[[:human genes:n:ndufb6|NDUFB6]]|0.478|
|[[:human genes:n:ndufa8|NDUFA8]]|0.478|
|[[:human genes:m:mrpl43|MRPL43]]|0.478|
|[[:human genes:n:ndufb8|NDUFB8]]|0.474|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.472|
|[[:human genes:n:ndufs7|NDUFS7]]|0.472|
|[[:human genes:n:ndufa5|NDUFA5]]|0.47|
|[[:human genes:m:mto1|MTO1]]|0.47|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.469|
|[[:human genes:m:mrps21|MRPS21]]|0.468|
|[[:human genes:n:ndufs5|NDUFS5]]|0.468|
|[[:human genes:e:ecsit|ECSIT]]|0.466|
|[[:human genes:m:mtif2|MTIF2]]|0.463|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.457|
|[[:human genes:p:pet117|PET117]]|0.454|
|[[:human genes:s:slc25a51|SLC25A51]]|0.452|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.451|
|[[:human genes:n:ndufa9|NDUFA9]]|0.45|
|[[:human genes:n:ndufs8|NDUFS8]]|0.449|
|[[:human genes:m:mettl17|METTL17]]|0.448|
|[[:human genes:m:mrpl17|MRPL17]]|0.445|
|[[:human genes:m:mrp63|MRP63]]|0.442|
|[[:human genes:m:mrpl14|MRPL14]]|0.442|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.441|
|[[:human genes:n:ndufv2|NDUFV2]]|0.44|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.439|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.439|
|[[:human genes:f:fastkd2|FASTKD2]]|0.436|
|[[:human genes:m:mrps27|MRPS27]]|0.433|
|[[:human genes:m:mrps25|MRPS25]]|0.432|
|[[:human genes:n:ndufb5|NDUFB5]]|0.432|
|[[:human genes:n:ndufb2|NDUFB2]]|0.43|
|[[:human genes:c:chchd1|CHCHD1]]|0.428|
|[[:human genes:n:noa1|NOA1]]|0.427|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.424|
|[[:human genes:n:nsun4|NSUN4]]|0.421|
|[[:human genes:c:clpp|CLPP]]|0.417|
|[[:human genes:f:ftsj2|FTSJ2]]|0.417|
|[[:human genes:g:gfm1|GFM1]]|0.416|
|[[:human genes:w:wbscr16|WBSCR16]]|0.415|
|[[:human genes:p:prepl|PREPL]]|0.414|
|[[:human genes:i:ict1|ICT1]]|0.413|
|[[:human genes:e:eral1|ERAL1]]|0.413|
|[[:human genes:n:ndufa6|NDUFA6]]|0.412|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.411|
|[[:human genes:s:slc25a3|SLC25A3]]|0.411|
|[[:human genes:m:mrps16|MRPS16]]|0.41|
|[[:human genes:p:pet112|PET112]]|0.41|
|[[:human genes:r:rpusd3|RPUSD3]]|0.409|
|[[:human genes:p:ptcd3|PTCD3]]|0.408|
|[[:human genes:m:mterfd1|MTERFD1]]|0.407|
|[[:human genes:m:mrpl1|MRPL1]]|0.406|
|[[:human genes:m:mrps7|MRPS7]]|0.405|
|[[:human genes:c:coq7|COQ7]]|0.405|
|[[:human genes:c:cars2|CARS2]]|0.404|
|[[:human genes:c:c1qbp|C1QBP]]|0.403|
|[[:human genes:m:mrpl21|MRPL21]]|0.402|
|[[:human genes:q:qrsl1|QRSL1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 82/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|1/26|
|breast|5/33|
|central nervous system|5/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|7/20|
|lung|9/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1707
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB4 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>