NDUFC1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFC1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4717|4717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43677|O43677]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.8|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.7|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.74|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.84|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.9|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.05|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.29|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.4|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.45|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa11|NDUFA11]]|0.636|
|[[:human genes:n:ndufb11|NDUFB11]]|0.633|
|[[:human genes:n:ndufa2|NDUFA2]]|0.612|
|[[:human genes:n:ndufb9|NDUFB9]]|0.608|
|[[:human genes:n:ndufa1|NDUFA1]]|0.605|
|[[:human genes:n:ndufs2|NDUFS2]]|0.604|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.602|
|[[:human genes:n:ndufc2|NDUFC2]]|0.587|
|[[:human genes:a:acad9|ACAD9]]|0.58|
|[[:human genes:n:ndufa3|NDUFA3]]|0.579|
|[[:human genes:g:grsf1|GRSF1]]|0.575|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.574|
|[[:human genes:n:nubpl|NUBPL]]|0.567|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.562|
|[[:human genes:n:ndufs3|NDUFS3]]|0.555|
|[[:human genes:n:ndufs5|NDUFS5]]|0.551|
|[[:human genes:m:mto1|MTO1]]|0.549|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.543|
|[[:human genes:f:fastkd2|FASTKD2]]|0.54|
|[[:human genes:n:ndufb6|NDUFB6]]|0.536|
|[[:human genes:n:ndufb7|NDUFB7]]|0.535|
|[[:human genes:n:ndufb10|NDUFB10]]|0.535|
|[[:human genes:n:ndufs1|NDUFS1]]|0.528|
|[[:human genes:n:ndufs8|NDUFS8]]|0.522|
|[[:human genes:m:mrps21|MRPS21]]|0.515|
|[[:human genes:n:ndufa6|NDUFA6]]|0.512|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.51|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.5|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.499|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.498|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.497|
|[[:human genes:n:ndufa13|NDUFA13]]|0.496|
|[[:human genes:n:ndufv2|NDUFV2]]|0.493|
|[[:human genes:n:ndufs7|NDUFS7]]|0.493|
|[[:human genes:n:ndufv1|NDUFV1]]|0.491|
|[[:human genes:n:ndufb4|NDUFB4]]|0.49|
|[[:human genes:e:ecsit|ECSIT]]|0.484|
|[[:human genes:r:rpusd3|RPUSD3]]|0.483|
|[[:human genes:n:ndufb2|NDUFB2]]|0.482|
|[[:human genes:l:lars2|LARS2]]|0.482|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.482|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.478|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.478|
|[[:human genes:p:pet117|PET117]]|0.473|
|[[:human genes:r:rmnd1|RMND1]]|0.472|
|[[:human genes:n:ndufa10|NDUFA10]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.467|
|[[:human genes:n:ndufb5|NDUFB5]]|0.462|
|[[:human genes:t:tmem261|TMEM261]]|0.455|
|[[:human genes:n:nars2|NARS2]]|0.454|
|[[:human genes:g:glrx5|GLRX5]]|0.449|
|[[:human genes:m:mrpl1|MRPL1]]|0.448|
|[[:human genes:s:ssbp1|SSBP1]]|0.447|
|[[:human genes:m:mettl17|METTL17]]|0.446|
|[[:human genes:m:malsu1|MALSU1]]|0.445|
|[[:human genes:c:clpp|CLPP]]|0.445|
|[[:human genes:m:mrpl41|MRPL41]]|0.444|
|[[:human genes:c:coq2|COQ2]]|0.444|
|[[:human genes:r:rbfa|RBFA]]|0.443|
|[[:human genes:n:ndufa8|NDUFA8]]|0.443|
|[[:human genes:q:qrsl1|QRSL1]]|0.441|
|[[:human genes:m:mrpl3|MRPL3]]|0.44|
|[[:human genes:m:mtif2|MTIF2]]|0.44|
|[[:human genes:c:cars2|CARS2]]|0.438|
|[[:human genes:p:polrmt|POLRMT]]|0.438|
|[[:human genes:m:mrps25|MRPS25]]|0.435|
|[[:human genes:n:ndufa5|NDUFA5]]|0.435|
|[[:human genes:m:mrpl21|MRPL21]]|0.434|
|[[:human genes:t:tfb1m|TFB1M]]|0.433|
|[[:human genes:c:c1qbp|C1QBP]]|0.431|
|[[:human genes:p:ptcd3|PTCD3]]|0.429|
|[[:human genes:i:iba57|IBA57]]|0.427|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:s:sfxn4|SFXN4]]|0.426|
|[[:human genes:m:mrpl13|MRPL13]]|0.426|
|[[:human genes:p:pet112|PET112]]|0.426|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.425|
|[[:human genes:t:tars2|TARS2]]|0.423|
|[[:human genes:m:mrpl44|MRPL44]]|0.423|
|[[:human genes:n:nsun4|NSUN4]]|0.423|
|[[:human genes:m:mrp63|MRP63]]|0.422|
|[[:human genes:d:dap3|DAP3]]|0.421|
|[[:human genes:m:mtg1|MTG1]]|0.42|
|[[:human genes:p:pars2|PARS2]]|0.419|
|[[:human genes:m:mrpl47|MRPL47]]|0.417|
|[[:human genes:f:ftsj2|FTSJ2]]|0.416|
|[[:human genes:n:ndufb8|NDUFB8]]|0.416|
|[[:human genes:s:selrc1|SELRC1]]|0.412|
|[[:human genes:y:yars2|YARS2]]|0.412|
|[[:human genes:m:mrpl15|MRPL15]]|0.41|
|[[:human genes:c:coq7|COQ7]]|0.41|
|[[:human genes:p:polg2|POLG2]]|0.41|
|[[:human genes:f:fars2|FARS2]]|0.409|
|[[:human genes:m:mtg2|MTG2]]|0.409|
|[[:human genes:e:eral1|ERAL1]]|0.408|
|[[:human genes:t:trub2|TRUB2]]|0.408|
|[[:human genes:n:noa1|NOA1]]|0.407|
|[[:human genes:m:mrps12|MRPS12]]|0.406|
|[[:human genes:m:mrps6|MRPS6]]|0.406|
|[[:human genes:n:ndufa9|NDUFA9]]|0.405|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.405|
|[[:human genes:m:mrpl23|MRPL23]]|0.405|
|[[:human genes:t:tefm|TEFM]]|0.404|
|[[:human genes:d:ddx28|DDX28]]|0.403|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.402|
|[[:human genes:p:prepl|PREPL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1460
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFC1 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>