NDUFS4 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS4
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit S4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4724|4724]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43181|O43181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:9463323}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ETC C1 NDUFA4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|positive regulation of fibroblast proliferation|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|regulation of fibroblast proliferation|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|response to cAMP|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|oxidative phosphorylation|
|response to organophosphorus|
|cAMP-mediated signaling|
|response to purine-containing compound|
|cellular respiration|
|cyclic-nucleotide-mediated signaling|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|second-messenger-mediated signaling|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|brain development|
|head development|
|cellular protein-containing complex assembly|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|oxidation-reduction process|
|central nervous system development|
|response to organonitrogen compound|
|response to nitrogen compound|
|mitochondrion|
|phosphorylation|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.75|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.84|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.91|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.94|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.15|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7166
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS4 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>