NDUFS5 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFS5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS5
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit S5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4725|4725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43920|O43920]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603847|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ndufs5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial intermembrane space|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.17|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.77|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.72|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.88|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.91|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.98|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.01|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.02|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.04|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.07|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.26|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.33|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.45|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.65|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufs2|NDUFS2]]|0.663|
|[[:human genes:n:ndufa1|NDUFA1]]|0.652|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.633|
|[[:human genes:n:ndufb11|NDUFB11]]|0.619|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.617|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.609|
|[[:human genes:n:ndufa11|NDUFA11]]|0.608|
|[[:human genes:a:acad9|ACAD9]]|0.601|
|[[:human genes:m:mto1|MTO1]]|0.592|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.589|
|[[:human genes:g:grsf1|GRSF1]]|0.582|
|[[:human genes:n:ndufa2|NDUFA2]]|0.572|
|[[:human genes:n:ndufv1|NDUFV1]]|0.571|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.571|
|[[:human genes:n:ndufb9|NDUFB9]]|0.566|
|[[:human genes:n:ndufa3|NDUFA3]]|0.561|
|[[:human genes:n:ndufc2|NDUFC2]]|0.552|
|[[:human genes:n:ndufc1|NDUFC1]]|0.551|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.543|
|[[:human genes:n:ndufs7|NDUFS7]]|0.535|
|[[:human genes:l:lars2|LARS2]]|0.534|
|[[:human genes:n:ndufa6|NDUFA6]]|0.531|
|[[:human genes:t:tfb1m|TFB1M]]|0.53|
|[[:human genes:n:ndufs8|NDUFS8]]|0.527|
|[[:human genes:n:nubpl|NUBPL]]|0.526|
|[[:human genes:n:ndufb7|NDUFB7]]|0.518|
|[[:human genes:n:ndufv2|NDUFV2]]|0.518|
|[[:human genes:n:ndufb6|NDUFB6]]|0.518|
|[[:human genes:e:ecsit|ECSIT]]|0.517|
|[[:human genes:n:ndufa8|NDUFA8]]|0.513|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.507|
|[[:human genes:f:fastkd2|FASTKD2]]|0.506|
|[[:human genes:r:rpusd3|RPUSD3]]|0.501|
|[[:human genes:f:ftsj2|FTSJ2]]|0.5|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.497|
|[[:human genes:c:cars2|CARS2]]|0.495|
|[[:human genes:n:ndufs1|NDUFS1]]|0.485|
|[[:human genes:p:pet117|PET117]]|0.485|
|[[:human genes:n:nars2|NARS2]]|0.484|
|[[:human genes:p:prepl|PREPL]]|0.483|
|[[:human genes:n:ndufb2|NDUFB2]]|0.48|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.479|
|[[:human genes:m:mettl17|METTL17]]|0.479|
|[[:human genes:g:gfm1|GFM1]]|0.478|
|[[:human genes:f:foxred1|FOXRED1]]|0.474|
|[[:human genes:n:ndufb10|NDUFB10]]|0.474|
|[[:human genes:n:ndufa10|NDUFA10]]|0.471|
|[[:human genes:n:ndufb4|NDUFB4]]|0.468|
|[[:human genes:n:ndufa13|NDUFA13]]|0.467|
|[[:human genes:t:tomm7|TOMM7]]|0.466|
|[[:human genes:m:mrps25|MRPS25]]|0.466|
|[[:human genes:t:tefm|TEFM]]|0.465|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.463|
|[[:human genes:m:malsu1|MALSU1]]|0.463|
|[[:human genes:a:atp5sl|ATP5SL]]|0.463|
|[[:human genes:m:mrps27|MRPS27]]|0.46|
|[[:human genes:g:gfm2|GFM2]]|0.46|
|[[:human genes:n:ndufs3|NDUFS3]]|0.456|
|[[:human genes:m:mterfd1|MTERFD1]]|0.456|
|[[:human genes:m:mrp63|MRP63]]|0.454|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.453|
|[[:human genes:w:wbscr16|WBSCR16]]|0.453|
|[[:human genes:p:pnpt1|PNPT1]]|0.451|
|[[:human genes:c:chchd1|CHCHD1]]|0.451|
|[[:human genes:q:qrsl1|QRSL1]]|0.448|
|[[:human genes:n:ndufa5|NDUFA5]]|0.448|
|[[:human genes:m:mrpl45|MRPL45]]|0.448|
|[[:human genes:c:c1qbp|C1QBP]]|0.447|
|[[:human genes:w:wars2|WARS2]]|0.445|
|[[:human genes:r:rbfa|RBFA]]|0.444|
|[[:human genes:e:eral1|ERAL1]]|0.443|
|[[:human genes:r:rmnd1|RMND1]]|0.443|
|[[:human genes:p:pet112|PET112]]|0.442|
|[[:human genes:n:ndufb5|NDUFB5]]|0.441|
|[[:human genes:s:slc31a1|SLC31A1]]|0.439|
|[[:human genes:c:coq2|COQ2]]|0.438|
|[[:human genes:c:coq7|COQ7]]|0.436|
|[[:human genes:d:dap3|DAP3]]|0.435|
|[[:human genes:t:tmem261|TMEM261]]|0.434|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.434|
|[[:human genes:p:pde12|PDE12]]|0.433|
|[[:human genes:m:mars2|MARS2]]|0.432|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.431|
|[[:human genes:m:mtif2|MTIF2]]|0.431|
|[[:human genes:m:mtg1|MTG1]]|0.424|
|[[:human genes:c:c12orf65|C12orf65]]|0.423|
|[[:human genes:m:mrpl21|MRPL21]]|0.422|
|[[:human genes:m:mrps21|MRPS21]]|0.421|
|[[:human genes:m:mrps18b|MRPS18B]]|0.421|
|[[:human genes:a:aars2|AARS2]]|0.42|
|[[:human genes:i:iba57|IBA57]]|0.417|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.417|
|[[:human genes:s:ssbp1|SSBP1]]|0.416|
|[[:human genes:d:dars2|DARS2]]|0.416|
|[[:human genes:y:yars2|YARS2]]|0.415|
|[[:human genes:v:vars2|VARS2]]|0.415|
|[[:human genes:m:mrps16|MRPS16]]|0.414|
|[[:human genes:m:mrpl4|MRPL4]]|0.414|
|[[:human genes:t:tsfm|TSFM]]|0.41|
|[[:human genes:m:mrpl44|MRPL44]]|0.41|
|[[:human genes:t:tars2|TARS2]]|0.41|
|[[:human genes:c:clpp|CLPP]]|0.409|
|[[:human genes:b:bcs1l|BCS1L]]|0.406|
|[[:human genes:p:polg2|POLG2]]|0.404|
|[[:human genes:r:rpusd4|RPUSD4]]|0.403|
|[[:human genes:s:selrc1|SELRC1]]|0.402|
|[[:human genes:t:trit1|TRIT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 231/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|11/28|
|bone|8/26|
|breast|14/33|
|central nervous system|12/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|5/21|
|liver|10/20|
|lung|24/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|4/24|
|peripheral nervous system|8/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS5 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>