NDUFS7 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NDUFS7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS7
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit S7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=374291|374291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75251|O75251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601825|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000305|PubMed:12611891}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Oxidored q6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|electron transport coupled proton transport|
|energy coupled proton transmembrane transport, against electrochemical gradient|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|quinone binding|
|NADH dehydrogenase activity|
|synaptic membrane|
|4 iron, 4 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|protease binding|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|neuron projection|
|mitochondrial matrix|
|neuronal cell body|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|ion transmembrane transport|
|oxidation-reduction process|
|transmembrane transport|
|phosphorylation|
|ion transport|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.72|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.87|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.87|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.88|
|[[:results:exp539|42°C R08 exp539]]|1.9|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.9|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.95|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.97|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.38|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.41|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa2|NDUFA2]]|0.628|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.626|
|[[:human genes:n:ndufb11|NDUFB11]]|0.624|
|[[:human genes:n:ndufa11|NDUFA11]]|0.624|
|[[:human genes:n:ndufs2|NDUFS2]]|0.616|
|[[:human genes:n:ndufa1|NDUFA1]]|0.61|
|[[:human genes:n:ndufa3|NDUFA3]]|0.606|
|[[:human genes:n:ndufb9|NDUFB9]]|0.582|
|[[:human genes:c:c17orf89|C17orf89]]|0.576|
|[[:human genes:n:ndufa8|NDUFA8]]|0.567|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.567|
|[[:human genes:n:ndufc2|NDUFC2]]|0.562|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.554|
|[[:human genes:n:ndufb5|NDUFB5]]|0.546|
|[[:human genes:e:ecsit|ECSIT]]|0.546|
|[[:human genes:g:grsf1|GRSF1]]|0.545|
|[[:human genes:m:mto1|MTO1]]|0.545|
|[[:human genes:n:ndufs8|NDUFS8]]|0.545|
|[[:human genes:c:c10orf2|C10orf2]]|0.537|
|[[:human genes:m:mrpl15|MRPL15]]|0.537|
|[[:human genes:a:acad9|ACAD9]]|0.536|
|[[:human genes:n:ndufb7|NDUFB7]]|0.536|
|[[:human genes:n:ndufs5|NDUFS5]]|0.535|
|[[:human genes:n:ndufb6|NDUFB6]]|0.535|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.534|
|[[:human genes:m:mrps5|MRPS5]]|0.532|
|[[:human genes:t:tefm|TEFM]]|0.531|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.529|
|[[:human genes:n:ndufv1|NDUFV1]]|0.521|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.518|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.517|
|[[:human genes:n:ndufs1|NDUFS1]]|0.513|
|[[:human genes:f:foxred1|FOXRED1]]|0.51|
|[[:human genes:m:mrps21|MRPS21]]|0.51|
|[[:human genes:f:ftsj2|FTSJ2]]|0.508|
|[[:human genes:m:mrp63|MRP63]]|0.505|
|[[:human genes:s:sars2|SARS2]]|0.501|
|[[:human genes:p:polg2|POLG2]]|0.498|
|[[:human genes:y:yars2|YARS2]]|0.498|
|[[:human genes:g:gfm2|GFM2]]|0.496|
|[[:human genes:c:coq2|COQ2]]|0.493|
|[[:human genes:n:ndufc1|NDUFC1]]|0.493|
|[[:human genes:m:mrpl53|MRPL53]]|0.492|
|[[:human genes:c:chchd1|CHCHD1]]|0.49|
|[[:human genes:q:qrsl1|QRSL1]]|0.488|
|[[:human genes:f:fars2|FARS2]]|0.487|
|[[:human genes:t:tmem261|TMEM261]]|0.483|
|[[:human genes:r:rpusd4|RPUSD4]]|0.481|
|[[:human genes:t:tufm|TUFM]]|0.481|
|[[:human genes:n:nubpl|NUBPL]]|0.48|
|[[:human genes:n:ndufa10|NDUFA10]]|0.48|
|[[:human genes:c:coq7|COQ7]]|0.48|
|[[:human genes:m:mrpl21|MRPL21]]|0.48|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.48|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.479|
|[[:human genes:d:dap3|DAP3]]|0.478|
|[[:human genes:m:mrps23|MRPS23]]|0.475|
|[[:human genes:r:rpusd3|RPUSD3]]|0.475|
|[[:human genes:m:mrps14|MRPS14]]|0.474|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.472|
|[[:human genes:n:ndufb4|NDUFB4]]|0.472|
|[[:human genes:a:atp5sl|ATP5SL]]|0.471|
|[[:human genes:c:c12orf65|C12orf65]]|0.471|
|[[:human genes:n:ndufb3|NDUFB3]]|0.47|
|[[:human genes:s:selrc1|SELRC1]]|0.47|
|[[:human genes:v:vars2|VARS2]]|0.467|
|[[:human genes:g:gatc|GATC]]|0.466|
|[[:human genes:n:ndufa6|NDUFA6]]|0.466|
|[[:human genes:r:rbfa|RBFA]]|0.463|
|[[:human genes:c:cars2|CARS2]]|0.462|
|[[:human genes:b:bcs1l|BCS1L]]|0.462|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.462|
|[[:human genes:c:cox6c|COX6C]]|0.461|
|[[:human genes:m:mettl17|METTL17]]|0.459|
|[[:human genes:t:tars2|TARS2]]|0.458|
|[[:human genes:m:mrpl23|MRPL23]]|0.457|
|[[:human genes:m:mrps25|MRPS25]]|0.456|
|[[:human genes:n:ndufb2|NDUFB2]]|0.456|
|[[:human genes:m:mrpl12|MRPL12]]|0.456|
|[[:human genes:w:wbscr16|WBSCR16]]|0.456|
|[[:human genes:n:ndufb10|NDUFB10]]|0.454|
|[[:human genes:n:nars2|NARS2]]|0.452|
|[[:human genes:g:gfm1|GFM1]]|0.452|
|[[:human genes:m:mrpl13|MRPL13]]|0.448|
|[[:human genes:n:ndufs3|NDUFS3]]|0.446|
|[[:human genes:p:pnpt1|PNPT1]]|0.445|
|[[:human genes:m:mrpl44|MRPL44]]|0.445|
|[[:human genes:f:fastkd5|FASTKD5]]|0.444|
|[[:human genes:n:ndufa13|NDUFA13]]|0.444|
|[[:human genes:t:tmem126b|TMEM126B]]|0.442|
|[[:human genes:e:ears2|EARS2]]|0.44|
|[[:human genes:m:mrpl45|MRPL45]]|0.437|
|[[:human genes:m:mrps26|MRPS26]]|0.437|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.432|
|[[:human genes:m:mrps24|MRPS24]]|0.431|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.43|
|[[:human genes:p:pdss1|PDSS1]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.429|
|[[:human genes:m:mrps33|MRPS33]]|0.428|
|[[:human genes:c:cox16|COX16]]|0.428|
|[[:human genes:m:mipep|MIPEP]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.425|
|[[:human genes:n:ndufa5|NDUFA5]]|0.422|
|[[:human genes:m:mtg1|MTG1]]|0.421|
|[[:human genes:c:cox5a|COX5A]]|0.42|
|[[:human genes:p:polg|POLG]]|0.419|
|[[:human genes:c:c1qbp|C1QBP]]|0.419|
|[[:human genes:i:iba57|IBA57]]|0.418|
|[[:human genes:s:sco2|SCO2]]|0.417|
|[[:human genes:m:mtif3|MTIF3]]|0.417|
|[[:human genes:m:mrps6|MRPS6]]|0.414|
|[[:human genes:m:mrps34|MRPS34]]|0.411|
|[[:human genes:m:malsu1|MALSU1]]|0.41|
|[[:human genes:t:tfam|TFAM]]|0.408|
|[[:human genes:n:ndufv2|NDUFV2]]|0.407|
|[[:human genes:t:timm21|TIMM21]]|0.407|
|[[:human genes:m:mrpl55|MRPL55]]|0.407|
|[[:human genes:m:mtg2|MTG2]]|0.406|
|[[:human genes:m:mtpap|MTPAP]]|0.405|
|[[:human genes:m:mrps16|MRPS16]]|0.405|
|[[:human genes:c:coq4|COQ4]]|0.404|
|[[:human genes:p:pars2|PARS2]]|0.404|
|[[:human genes:a:atp5d|ATP5D]]|0.404|
|[[:human genes:m:mrpl41|MRPL41]]|0.402|
|[[:human genes:m:mrpl38|MRPL38]]|0.401|
|[[:human genes:m:mterfd2|MTERFD2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS7 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>