NEFL [The Human Chemical-Genetic Interaction Map Project]

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======= NEFL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEFL
  * **<color #00a2e8>Official Name</color>**: neurofilament light
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4747|4747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07196|P07196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEFL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEFL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
|Filament head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intermediate filament polymerization or depolymerization|
|presynaptic intermediate filament cytoskeleton|
|response to acrylamide|
|postsynaptic intermediate filament cytoskeleton|
|neurofilament bundle assembly|
|postsynaptic intermediate filament cytoskeleton organization|
|structural constituent of postsynaptic intermediate filament cytoskeleton|
|regulation of axon diameter|
|response to sodium arsenite|
|peripheral nervous system axon regeneration|
|intermediate filament bundle assembly|
|neurofilament|
|neurofilament cytoskeleton organization|
|cholinergic synapse|
|synapse maturation|
|axonal transport of mitochondrion|
|response to herbicide|
|regulation of cell projection size|
|postsynaptic cytoskeleton organization|
|phospholipase binding|
|response to insecticide|
|retrograde axonal transport|
|response to salt|
|response to corticosterone|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|axon regeneration|
|intermediate filament organization|
|establishment of mitochondrion localization|
|neuron projection regeneration|
|response to arsenic-containing substance|
|response to mineralocorticoid|
|regulation of NMDA receptor activity|
|anterograde axonal transport|
|mitochondrion localization|
|response to axon injury|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|neuromuscular process controlling balance|
|axonal transport|
|axon cytoplasm|
|regulation of glutamate receptor signaling pathway|
|axo-dendritic transport|
|regulation of neurotransmitter receptor activity|
|neuromuscular junction|
|protein binding, bridging|
|organelle transport along microtubule|
|hippocampus development|
|Schaffer collateral - CA1 synapse|
|positive regulation of axonogenesis|
|protein polymerization|
|postsynapse organization|
|response to antineoplastic agent|
|structural constituent of cytoskeleton|
|spinal cord development|
|neuromuscular process|
|limbic system development|
|cerebral cortex development|
|growth cone|
|response to glucocorticoid|
|negative regulation of neuron apoptotic process|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|regeneration|
|response to corticosteroid|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|pallium development|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|regulation of axonogenesis|
|protein C-terminus binding|
|response to ketone|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|response to alcohol|
|developmental maturation|
|protein domain specific binding|
|regulation of ion transmembrane transporter activity|
|telencephalon development|
|regulation of transmembrane transporter activity|
|synapse organization|
|microtubule-based movement|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|axon|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|response to steroid hormone|
|regulation of cation transmembrane transport|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|MAPK cascade|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|axon development|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|response to toxic substance|
|cell part morphogenesis|
|regulation of anatomical structure size|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of transmembrane transport|
|response to wounding|
|organelle localization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to nitrogen compound|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEFL Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>