NELFCD [The Human Chemical-Genetic Interaction Map Project]

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======= NELFCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NELFCD
  * **<color #00a2e8>Official Name</color>**: negative elongation factor complex member C/D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51497|51497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXH7|Q8IXH7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NELFCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NELFCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NELF complex|
|negative regulation of transcription elongation from RNA polymerase II promoter|
|negative regulation of DNA-templated transcription, elongation|
|regulation of transcription elongation from RNA polymerase II promoter|
|positive regulation of viral transcription|
|regulation of DNA-templated transcription, elongation|
|regulation of viral transcription|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|positive regulation of viral process|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|transcription by RNA polymerase II|
|positive regulation of multi-organism process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of multi-organism process|
|negative regulation of transcription by RNA polymerase II|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.1|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.93|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.92|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.9|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.8|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.477|
|[[:human genes:n:nelfa|NELFA]]|0.475|
|[[:human genes:p:prim1|PRIM1]]|0.47|
|[[:human genes:p:psmb2|PSMB2]]|0.445|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:p:psmb1|PSMB1]]|0.428|
|[[:human genes:r:rrp7a|RRP7A]]|0.424|
|[[:human genes:c:ccdc116|CCDC116]]|0.423|
|[[:human genes:n:nelfb|NELFB]]|0.421|
|[[:human genes:p:psmd2|PSMD2]]|0.42|
|[[:human genes:p:prpf3|PRPF3]]|0.417|
|[[:human genes:b:brd2|BRD2]]|0.411|
|[[:human genes:r:rpl35|RPL35]]|0.407|
|[[:human genes:t:tsg101|TSG101]]|0.405|
|[[:human genes:i:ints5|INTS5]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.404|
|[[:human genes:c:chd4|CHD4]]|0.403|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.403|
|[[:human genes:p:psmd14|PSMD14]]|0.403|
|[[:human genes:m:mt1e|MT1E]]|0.402|
|[[:human genes:p:psmc5|PSMC5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|2/25|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NELFCD Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>