NEUROD1 [The Human Chemical-Genetic Interaction Map Project]

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======= NEUROD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEUROD1
  * **<color #00a2e8>Official Name</color>**: neuronal differentiation 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4760|4760]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13562|Q13562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEUROD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEUROD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601724|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
|Neuro bHLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pancreatic A cell fate commitment|
|regulation of intestinal epithelial structure maintenance|
|pancreatic PP cell fate commitment|
|pancreatic PP cell differentiation|
|amacrine cell differentiation|
|negative regulation of type B pancreatic cell apoptotic process|
|pancreatic A cell differentiation|
|regulation of type B pancreatic cell apoptotic process|
|epithelial cell fate commitment|
|dentate gyrus development|
|signal transduction involved in regulation of gene expression|
|enteroendocrine cell differentiation|
|negative regulation of receptor signaling pathway via JAK-STAT|
|nitric oxide mediated signal transduction|
|negative regulation of receptor signaling pathway via STAT|
|positive regulation of transcription regulatory region DNA binding|
|glandular epithelial cell differentiation|
|endocrine pancreas development|
|insulin secretion|
|regulation of digestive system process|
|negative regulation of epithelial cell apoptotic process|
|E-box binding|
|regulation of transcription regulatory region DNA binding|
|RNA polymerase II activating transcription factor binding|
|positive regulation of DNA binding|
|neural retina development|
|peptide hormone secretion|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|RNA polymerase II transcription factor complex|
|cellular response to monosaccharide stimulus|
|hormone secretion|
|pancreas development|
|regulation of epithelial cell apoptotic process|
|cellular response to carbohydrate stimulus|
|hippocampus development|
|hormone transport|
|cellular glucose homeostasis|
|columnar/cuboidal epithelial cell differentiation|
|cerebellum development|
|regulation of cell cycle arrest|
|limbic system development|
|metencephalon development|
|endocrine system development|
|regulation of DNA binding|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|response to glucose|
|retina development in camera-type eye|
|response to hexose|
|response to monosaccharide|
|hindbrain development|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|pallium development|
|peptide secretion|
|positive regulation of binding|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|inner ear development|
|regulation of peptide hormone secretion|
|anterior/posterior pattern specification|
|ear development|
|cell fate commitment|
|telencephalon development|
|positive regulation of DNA-binding transcription factor activity|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of hormone secretion|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|camera-type eye development|
|regionalization|
|transcription factor binding|
|second-messenger-mediated signaling|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|regulation of binding|
|forebrain development|
|chromatin binding|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|regulation of peptide secretion|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|embryonic morphogenesis|
|regulation of system process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|head development|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|secretion by cell|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|secretion|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.05|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.02|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.9|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.84|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.7|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.7|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.7|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.73|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.85|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.86|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.06|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEUROD1 Expression in NALM6 Cells: -0.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>