NFKBIA [The Human Chemical-Genetic Interaction Map Project]

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======= NFKBIA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFKBIA
  * **<color #00a2e8>Official Name</color>**: NFKB inhibitor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4792|4792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25963|P25963]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFKBIA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFKBIA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164008|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|I-kappaB/NF-kappaB complex|
|nucleotide-binding oligomerization domain containing 1 signaling pathway|
|nucleotide-binding oligomerization domain containing 2 signaling pathway|
|cytoplasmic sequestering of NF-kappaB|
|cellular response to cold|
|negative regulation of macrophage derived foam cell differentiation|
|positive regulation of cholesterol efflux|
|cytoplasmic sequestering of transcription factor|
|response to muscle stretch|
|toll-like receptor 4 signaling pathway|
|negative regulation of lipid storage|
|response to muramyl dipeptide|
|positive regulation of sterol transport|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|cytoplasmic sequestering of protein|
|nuclear localization sequence binding|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|regulation of macrophage derived foam cell differentiation|
|NF-kappaB binding|
|lipopolysaccharide-mediated signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of lipid localization|
|negative regulation of Notch signaling pathway|
|response to exogenous dsRNA|
|regulation of cholesterol transport|
|regulation of lipid storage|
|regulation of sterol transport|
|response to cold|
|response to dsRNA|
|negative regulation of DNA binding|
|positive regulation of lipid transport|
|I-kappaB kinase/NF-kappaB signaling|
|negative regulation of myeloid cell differentiation|
|positive regulation of lipid localization|
|negative regulation of NF-kappaB transcription factor activity|
|protein import into nucleus|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|regulation of Notch signaling pathway|
|maintenance of protein location|
|regulation of lipid transport|
|regulation of NIK/NF-kappaB signaling|
|import into nucleus|
|tumor necrosis factor-mediated signaling pathway|
|regulation of DNA binding|
|pattern recognition receptor signaling pathway|
|negative regulation of hemopoiesis|
|regulation of lipid localization|
|positive regulation of inflammatory response|
|protein import|
|negative regulation of DNA-binding transcription factor activity|
|protein localization to nucleus|
|maintenance of location|
|intracellular receptor signaling pathway|
|negative regulation of binding|
|cellular response to interleukin-1|
|response to temperature stimulus|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|regulation of myeloid cell differentiation|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|activation of innate immune response|
|nucleocytoplasmic transport|
|response to tumor necrosis factor|
|nuclear transport|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|transcription factor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|enzyme binding|
|positive regulation of response to biotic stimulus|
|regulation of binding|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|response to bacterium|
|viral process|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|intracellular protein transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.92|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.74|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.67|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.07|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.533|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFKBIA Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>