NFU1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NFU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFU1
  * **<color #00a2e8>Official Name</color>**: NFU1 iron-sulfur cluster scaffold
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27247|27247]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UMS0|Q9UMS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins. {ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104, ECO:0000269|PubMed:28906594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nfu N|
|NifU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein maturation by iron-sulfur cluster transfer|
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|4 iron, 4 sulfur cluster binding|
|iron ion binding|
|cofactor biosynthetic process|
|protein maturation|
|sulfur compound metabolic process|
|cofactor metabolic process|
|mitochondrion|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.35|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.06|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.04|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.82|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.73|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.73|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.74|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.78|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.85|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.87|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.88|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.07|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.14|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.15|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.18|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.23|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.34|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.42|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.52|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.69|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.74|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.04|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|3.12|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.4|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.68|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:glrx5|GLRX5]]|0.661|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.647|
|[[:human genes:i:isca2|ISCA2]]|0.616|
|[[:human genes:s:slc25a26|SLC25A26]]|0.606|
|[[:human genes:i:iba57|IBA57]]|0.597|
|[[:human genes:n:ndufb11|NDUFB11]]|0.58|
|[[:human genes:n:ndufa1|NDUFA1]]|0.537|
|[[:human genes:c:c12orf65|C12orf65]]|0.517|
|[[:human genes:n:ndufb5|NDUFB5]]|0.517|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.516|
|[[:human genes:n:ndufb9|NDUFB9]]|0.509|
|[[:human genes:n:ndufa3|NDUFA3]]|0.507|
|[[:human genes:n:nubpl|NUBPL]]|0.505|
|[[:human genes:n:ndufs2|NDUFS2]]|0.494|
|[[:human genes:c:c17orf89|C17orf89]]|0.493|
|[[:human genes:d:dars2|DARS2]]|0.492|
|[[:human genes:n:ndufv1|NDUFV1]]|0.481|
|[[:human genes:n:ndufb6|NDUFB6]]|0.478|
|[[:human genes:t:tpk1|TPK1]]|0.474|
|[[:human genes:n:ndufc2|NDUFC2]]|0.47|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.468|
|[[:human genes:s:slc25a19|SLC25A19]]|0.467|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.466|
|[[:human genes:g:gfm1|GFM1]]|0.463|
|[[:human genes:e:ecsit|ECSIT]]|0.461|
|[[:human genes:n:ndufa10|NDUFA10]]|0.46|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.459|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.458|
|[[:human genes:s:sucla2|SUCLA2]]|0.458|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.457|
|[[:human genes:m:mipep|MIPEP]]|0.457|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.452|
|[[:human genes:m:mrps21|MRPS21]]|0.451|
|[[:human genes:s:sco2|SCO2]]|0.45|
|[[:human genes:r:rbfa|RBFA]]|0.45|
|[[:human genes:w:wbscr16|WBSCR16]]|0.45|
|[[:human genes:n:ndufa11|NDUFA11]]|0.449|
|[[:human genes:y:yars2|YARS2]]|0.449|
|[[:human genes:m:mrps16|MRPS16]]|0.448|
|[[:human genes:m:mrpl21|MRPL21]]|0.447|
|[[:human genes:m:mto1|MTO1]]|0.446|
|[[:human genes:r:rpusd4|RPUSD4]]|0.445|
|[[:human genes:m:mrp63|MRP63]]|0.444|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.444|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.444|
|[[:human genes:m:mrps14|MRPS14]]|0.443|
|[[:human genes:b:bcs1l|BCS1L]]|0.443|
|[[:human genes:n:ndufa2|NDUFA2]]|0.441|
|[[:human genes:a:acad9|ACAD9]]|0.438|
|[[:human genes:c:cox16|COX16]]|0.437|
|[[:human genes:m:mrps5|MRPS5]]|0.437|
|[[:human genes:a:atic|ATIC]]|0.436|
|[[:human genes:m:mrps34|MRPS34]]|0.435|
|[[:human genes:d:dap3|DAP3]]|0.435|
|[[:human genes:f:fdx1|FDX1]]|0.434|
|[[:human genes:a:atp5sl|ATP5SL]]|0.434|
|[[:human genes:m:mrps33|MRPS33]]|0.433|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.432|
|[[:human genes:m:mrps36|MRPS36]]|0.43|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.43|
|[[:human genes:g:gfm2|GFM2]]|0.429|
|[[:human genes:m:mrps26|MRPS26]]|0.429|
|[[:human genes:m:mcat|MCAT]]|0.428|
|[[:human genes:n:ndufb2|NDUFB2]]|0.425|
|[[:human genes:n:ndufa5|NDUFA5]]|0.416|
|[[:human genes:f:fars2|FARS2]]|0.413|
|[[:human genes:s:suclg1|SUCLG1]]|0.411|
|[[:human genes:l:lipt2|LIPT2]]|0.41|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.408|
|[[:human genes:t:trmt10c|TRMT10C]]|0.408|
|[[:human genes:f:foxred1|FOXRED1]]|0.407|
|[[:human genes:p:pnpt1|PNPT1]]|0.406|
|[[:human genes:t:tufm|TUFM]]|0.403|
|[[:human genes:m:mrpl23|MRPL23]]|0.402|
|[[:human genes:m:mrpl15|MRPL15]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFU1 Expression in NALM6 Cells: 3.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>