NFYB [The Human Chemical-Genetic Interaction Map Project]

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======= NFYB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFYB
  * **<color #00a2e8>Official Name</color>**: nuclear transcription factor Y subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4801|4801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25208|P25208]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFYB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFYB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCAAT-binding factor complex|
|repressing transcription factor binding|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|protein-DNA complex|
|regulation of cholesterol metabolic process|
|RNA polymerase II transcription factor complex|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of steroid metabolic process|
|regulation of lipid biosynthetic process|
|transcription regulatory region DNA binding|
|protein-containing complex binding|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|protein heterodimerization activity|
|DNA-binding transcription factor activity|
|cellular response to cytokine stimulus|
|response to cytokine|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.7|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.75|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.87|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.02|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.47|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nfyc|NFYC]]|0.452|
|[[:human genes:c:cox8a|COX8A]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 129/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|6/28|
|bone|6/25|
|breast|8/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|2/21|
|liver|3/20|
|lung|15/75|
|lymphocyte|4/14|
|ovary|6/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1548
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFYB Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>