NFYC [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NFYC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFYC
  * **<color #00a2e8>Official Name</color>**: nuclear transcription factor Y subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4802|4802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13952|Q13952]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFYC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFYC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605344|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFD NFYB HMF|
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCAAT-binding factor complex|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|protein-DNA complex|
|regulation of cholesterol metabolic process|
|RNA polymerase II transcription factor complex|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of steroid metabolic process|
|regulation of lipid biosynthetic process|
|transcription regulatory region DNA binding|
|protein folding|
|transcription coactivator activity|
|transcription factor binding|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA-binding transcription factor activity|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.94|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.96|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.96|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.07|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.11|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.16|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.32|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.59|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nfyb|NFYB]]|0.452|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 337/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|11/28|
|bone|7/25|
|breast|16/33|
|central nervous system|19/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|5/15|
|kidney|7/21|
|liver|9/20|
|lung|44/75|
|lymphocyte|3/14|
|ovary|11/26|
|pancreas|14/24|
|peripheral nervous system|5/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1991
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFYC Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>