NGDN [The Human Chemical-Genetic Interaction Map Project]

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======= NGDN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NGDN
  * **<color #00a2e8>Official Name</color>**: neuroguidin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25983|25983]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEJ9|Q8NEJ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NGDN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NGDN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sas10 Utp3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|chromosome, centromeric region|
|ribosomal small subunit biogenesis|
|filopodium|
|rRNA processing|
|rRNA metabolic process|
|axon|
|ribosome biogenesis|
|regulation of translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|dendrite|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|nucleolus|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.86|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.82|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.7|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.72|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.75|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.81|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.87|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.09|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.35|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.35|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.461|
|[[:human genes:s:sart1|SART1]]|0.452|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.442|
|[[:human genes:r:rps7|RPS7]]|0.442|
|[[:human genes:b:bysl|BYSL]]|0.43|
|[[:human genes:n:npipb5|NPIPB5]]|0.425|
|[[:human genes:p:polr2i|POLR2I]]|0.421|
|[[:human genes:c:chd4|CHD4]]|0.417|
|[[:human genes:r:rpl35|RPL35]]|0.415|
|[[:human genes:e:exosc9|EXOSC9]]|0.414|
|[[:human genes:r:rpl6|RPL6]]|0.413|
|[[:human genes:p:pola1|POLA1]]|0.412|
|[[:human genes:t:tceb3c|TCEB3C]]|0.411|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:p:psma6|PSMA6]]|0.407|
|[[:human genes:r:rps10|RPS10]]|0.405|
|[[:human genes:m:med28|MED28]]|0.405|
|[[:human genes:w:wdr75|WDR75]]|0.401|
|[[:human genes:p:psmb2|PSMB2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NGDN Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>