NGF [The Human Chemical-Genetic Interaction Map Project]

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======= NGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NGF
  * **<color #00a2e8>Official Name</color>**: nerve growth factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4803|4803]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01138|P01138]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). {ECO:0000269|PubMed:20164177}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nerve growth factor receptor binding|
|nerve growth factor processing|
|positive regulation of collateral sprouting|
|nerve growth factor signaling pathway|
|metalloendopeptidase inhibitor activity|
|neurotrophin TRK receptor signaling pathway|
|regulation of collateral sprouting|
|neurotrophin signaling pathway|
|peptide hormone processing|
|extrinsic apoptotic signaling pathway via death domain receptors|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|activation of MAPKK activity|
|positive regulation of DNA binding|
|positive regulation of Ras protein signal transduction|
|positive regulation of small GTPase mediated signal transduction|
|phosphatidylinositol-mediated signaling|
|peripheral nervous system development|
|inositol lipid-mediated signaling|
|nerve development|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of axonogenesis|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|extrinsic apoptotic signaling pathway|
|Golgi lumen|
|regulation of extent of cell growth|
|memory|
|synaptic vesicle|
|regulation of DNA binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of neuron apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of cell morphogenesis involved in differentiation|
|protein processing|
|growth factor activity|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|positive regulation of endopeptidase activity|
|positive regulation of binding|
|regulation of cell size|
|regulation of axonogenesis|
|positive regulation of peptidase activity|
|hormone metabolic process|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein maturation|
|regulation of cysteine-type endopeptidase activity|
|regulation of Ras protein signal transduction|
|negative regulation of endopeptidase activity|
|cytoplasmic vesicle|
|negative regulation of peptidase activity|
|positive regulation of growth|
|learning or memory|
|positive regulation of MAP kinase activity|
|positive regulation of neuron projection development|
|apoptotic signaling pathway|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of neuron differentiation|
|regulation of binding|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of endopeptidase activity|
|regulation of cell growth|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|peptide metabolic process|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|behavior|
|positive regulation of kinase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|system process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NGF Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>