NISCH [The Human Chemical-Genetic Interaction Map Project]

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======= NISCH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NISCH
  * **<color #00a2e8>Official Name</color>**: nischarin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11188|11188]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2I1|Q9Y2I1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NISCH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NISCH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615507|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|norepinephrine secretion|
|norepinephrine transport|
|catecholamine secretion|
|catecholamine transport|
|monoamine transport|
|Rac protein signal transduction|
|regulation of synaptic transmission, GABAergic|
|phosphatidylinositol binding|
|glucose metabolic process|
|recycling endosome|
|integrin binding|
|organic hydroxy compound transport|
|hexose metabolic process|
|regulation of blood pressure|
|monosaccharide metabolic process|
|Ras protein signal transduction|
|early endosome|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|blood circulation|
|circulatory system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein kinase binding|
|carbohydrate metabolic process|
|actin cytoskeleton organization|
|actin filament-based process|
|regulation of cell migration|
|regulation of cell motility|
|apoptotic process|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|programmed cell death|
|identical protein binding|
|cell death|
|cytoskeleton organization|
|secretion|
|intracellular signal transduction|
|small molecule metabolic process|
|nitrogen compound transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.95|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.87|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.76|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7709
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NISCH Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>