NKD1 [The Human Chemical-Genetic Interaction Map Project]

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======= NKD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKD1
  * **<color #00a2e8>Official Name</color>**: NKD inhibitor of WNT signaling pathway 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85407|85407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969G9|Q969G9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of convergent extension involved in axis elongation|
|positive regulation of non-canonical Wnt signaling pathway via JNK cascade|
|regulation of cell motility involved in somitogenic axis elongation|
|negative regulation of convergent extension involved in axis elongation|
|regulation of non-canonical Wnt signaling pathway via JNK cascade|
|somatic muscle development|
|regulation of somitogenesis|
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|positive regulation of non-canonical Wnt signaling pathway|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|negative regulation of morphogenesis of an epithelium|
|protein phosphatase type 2A complex|
|regulation of non-canonical Wnt signaling pathway|
|eye photoreceptor cell differentiation|
|photoreceptor cell differentiation|
|PDZ domain binding|
|negative regulation of developmental growth|
|regulation of establishment of planar polarity|
|regulation of embryonic development|
|eye morphogenesis|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|negative regulation of growth|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|regulation of developmental growth|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|regulation of Wnt signaling pathway|
|sensory system development|
|regulation of protein catabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|muscle structure development|
|sensory organ development|
|regulation of growth|
|calcium ion binding|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKD1 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>