NLGN2 [The Human Chemical-Genetic Interaction Map Project]

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======= NLGN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLGN2
  * **<color #00a2e8>Official Name</color>**: neuroligin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57555|57555]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFZ4|Q8NFZ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLGN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLGN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|terminal button organization|
|gephyrin clustering involved in postsynaptic density assembly|
|symmetric, GABA-ergic, inhibitory synapse|
|positive regulation of synaptic vesicle clustering|
|postsynaptic density protein 95 clustering|
|modulation of inhibitory postsynaptic potential|
|glycinergic synapse|
|positive regulation of inhibitory postsynaptic potential|
|postsynaptic density assembly|
|spanning component of membrane|
|regulation of synaptic vesicle clustering|
|inhibitory synapse assembly|
|postsynaptic specialization assembly|
|presynaptic membrane assembly|
|positive regulation of protein localization to synapse|
|presynaptic membrane organization|
|positive regulation of synaptic transmission, GABAergic|
|cell-cell junction maintenance|
|postsynaptic membrane assembly|
|regulation of respiratory gaseous exchange by nervous system process|
|dopaminergic synapse|
|locomotory exploration behavior|
|neurexin family protein binding|
|excitatory synapse assembly|
|inhibitory synapse|
|cell junction maintenance|
|regulation of respiratory system process|
|neuron cell-cell adhesion|
|postsynaptic density organization|
|postsynaptic specialization organization|
|presynapse assembly|
|postsynapse assembly|
|presynapse organization|
|regulation of respiratory gaseous exchange|
|regulation of AMPA receptor activity|
|regulation of protein localization to synapse|
|exploration behavior|
|integral component of postsynaptic specialization membrane|
|positive regulation of excitatory postsynaptic potential|
|postsynaptic membrane organization|
|positive regulation of synaptic transmission, glutamatergic|
|regulation of synaptic transmission, GABAergic|
|membrane assembly|
|membrane biogenesis|
|modulation of excitatory postsynaptic potential|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|integral component of postsynaptic membrane|
|cellular component maintenance|
|synaptic vesicle recycling|
|neuromuscular process controlling balance|
|cell adhesion molecule binding|
|positive regulation of nervous system process|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|positive regulation of synapse assembly|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of insulin secretion|
|presynaptic membrane|
|regulation of neurotransmitter receptor activity|
|sensory perception of pain|
|postsynapse organization|
|synapse assembly|
|positive regulation of peptide hormone secretion|
|regulation of synapse assembly|
|neuromuscular process|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|positive regulation of hormone secretion|
|vesicle-mediated transport in synapse|
|regulation of nervous system process|
|cell-cell junction organization|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of insulin secretion|
|locomotory behavior|
|postsynaptic membrane|
|signaling receptor activity|
|regulation of peptide hormone secretion|
|cell junction organization|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|synapse|
|synapse organization|
|positive regulation of protein secretion|
|regulation of transporter activity|
|positive regulation of peptide secretion|
|regulation of cation transmembrane transport|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|regulation of peptide secretion|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|regulation of hormone levels|
|positive regulation of nervous system development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cell surface|
|import into cell|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|sensory perception|
|positive regulation of transport|
|regulation of protein localization|
|identical protein binding|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLGN2 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>