NLGN3 [The Human Chemical-Genetic Interaction Map Project]

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======= NLGN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLGN3
  * **<color #00a2e8>Official Name</color>**: neuroligin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54413|54413]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ94|Q9NZ94]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLGN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLGN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300336|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of terminal button organization|
|symmetric, GABA-ergic, inhibitory synapse|
|rhythmic synaptic transmission|
|positive regulation of synaptic vesicle clustering|
|asymmetric, glutamatergic, excitatory synapse|
|spanning component of membrane|
|negative regulation of dendritic spine morphogenesis|
|positive regulation of AMPA receptor activity|
|regulation of synaptic vesicle clustering|
|presynaptic membrane assembly|
|negative regulation of excitatory postsynaptic potential|
|inhibitory postsynaptic potential|
|presynaptic membrane organization|
|postsynaptic membrane assembly|
|negative regulation of dendritic spine development|
|regulation of respiratory gaseous exchange by nervous system process|
|neurexin family protein binding|
|regulation of respiratory system process|
|positive regulation of glutamate receptor signaling pathway|
|negative regulation of dendrite morphogenesis|
|neuron cell-cell adhesion|
|vocalization behavior|
|presynapse assembly|
|postsynapse assembly|
|presynapse organization|
|regulation of respiratory gaseous exchange|
|negative regulation of synapse organization|
|regulation of AMPA receptor activity|
|negative regulation of nervous system process|
|positive regulation of excitatory postsynaptic potential|
|negative regulation of dendrite development|
|postsynaptic membrane organization|
|regulation of presynapse organization|
|excitatory synapse|
|positive regulation of synaptic transmission, glutamatergic|
|membrane assembly|
|positive regulation of signaling receptor activity|
|axon extension|
|regulation of NMDA receptor activity|
|membrane biogenesis|
|modulation of excitatory postsynaptic potential|
|regulation of dendritic spine morphogenesis|
|regulation of long-term synaptic potentiation|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|integral component of postsynaptic membrane|
|long-term synaptic potentiation|
|visual learning|
|synaptic vesicle recycling|
|intraspecies interaction between organisms|
|social behavior|
|visual behavior|
|cell adhesion molecule binding|
|endocytic vesicle|
|scaffold protein binding|
|neuron projection extension|
|negative regulation of synaptic transmission|
|positive regulation of nervous system process|
|excitatory postsynaptic potential|
|regulation of glutamate receptor signaling pathway|
|positive regulation of synapse assembly|
|multi-organism behavior|
|chemical synaptic transmission, postsynaptic|
|positive regulation of cation channel activity|
|oligodendrocyte differentiation|
|regulation of synaptic transmission, glutamatergic|
|regulation of dendritic spine development|
|regulation of neurotransmitter receptor activity|
|associative learning|
|postsynapse organization|
|developmental cell growth|
|cell growth|
|regulation of dendrite morphogenesis|
|synapse assembly|
|presynapse|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of postsynaptic membrane potential|
|positive regulation of ion transmembrane transporter activity|
|regulation of synapse assembly|
|positive regulation of transporter activity|
|regulation of synaptic vesicle cycle|
|developmental growth involved in morphogenesis|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of nervous system process|
|positive regulation of cation transmembrane transport|
|adult behavior|
|learning|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|negative regulation of neuron projection development|
|positive regulation of ion transmembrane transport|
|glial cell differentiation|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|negative regulation of cell projection organization|
|regulation of synaptic plasticity|
|positive regulation of transmembrane transport|
|signaling receptor activity|
|gliogenesis|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|receptor-mediated endocytosis|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|synapse|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|negative regulation of neurogenesis|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|negative regulation of nervous system development|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cell surface|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|central nervous system development|
|positive regulation of transport|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLGN3 Expression in NALM6 Cells: 1.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>