NLRX1 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRX1
  * **<color #00a2e8>Official Name</color>**: NLR family member X1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79671|79671]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UT6|Q86UT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy- related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF- kappa-B signaling pathway, but enhances NF-kappa-B and JUN N- terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:27393910}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of RIG-I signaling pathway|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of interferon-beta production|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of defense response to virus|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of interleukin-6 production|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|negative regulation of innate immune response|
|regulation of defense response to virus|
|negative regulation of response to biotic stimulus|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|negative regulation of inflammatory response|
|regulation of interleukin-6 production|
|negative regulation of immune response|
|mitochondrial outer membrane|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of cytokine production|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|cell junction|
|regulation of cytokine production|
|viral process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|defense response to other organism|
|regulation of response to external stimulus|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.13|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.97|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4830
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRX1 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>