NMI [The Human Chemical-Genetic Interaction Map Project]

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======= NMI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NMI
  * **<color #00a2e8>Official Name</color>**: N-myc and STAT interactor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9111|9111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13287|Q13287]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NMI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NMI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IFP 35 N|
|NID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interferon-beta biosynthetic process|
|negative regulation of interferon-alpha biosynthetic process|
|positive regulation of protein K48-linked ubiquitination|
|regulation of protein K48-linked ubiquitination|
|negative regulation of interferon-alpha production|
|regulation of interferon-alpha biosynthetic process|
|regulation of interferon-beta biosynthetic process|
|positive regulation of protein polyubiquitination|
|negative regulation of interferon-beta production|
|regulation of protein polyubiquitination|
|regulation of interferon-alpha production|
|negative regulation of cytokine biosynthetic process|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|negative regulation of innate immune response|
|interferon-gamma-mediated signaling pathway|
|transcription coregulator activity|
|negative regulation of response to biotic stimulus|
|regulation of cytokine biosynthetic process|
|positive regulation of protein ubiquitination|
|regulation of type I interferon production|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of immune response|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|regulation of protein ubiquitination|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cytokine production|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|transcription by RNA polymerase II|
|inflammatory response|
|regulation of response to biotic stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|identical protein binding|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.71|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.76|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.78|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.82|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.85|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.98|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17731
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NMI Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>