NOC2L [The Human Chemical-Genetic Interaction Map Project]

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======= NOC2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOC2L
  * **<color #00a2e8>Official Name</color>**: NOC2 like nucleolar associated transcriptional repressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26155|26155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3T9|Q9Y3T9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOC2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOC2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Noc2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Noc1p-Noc2p complex|
|Noc2p-Noc3p complex|
|negative regulation of B cell apoptotic process|
|negative regulation of histone acetylation|
|regulation of B cell apoptotic process|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of protein acetylation|
|nucleosome binding|
|negative regulation of lymphocyte apoptotic process|
|repressing transcription factor binding|
|negative regulation of histone modification|
|negative regulation of leukocyte apoptotic process|
|regulation of lymphocyte apoptotic process|
|regulation of histone acetylation|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|regulation of protein acetylation|
|ribosomal large subunit biogenesis|
|regulation of leukocyte apoptotic process|
|cellular response to UV|
|negative regulation of intrinsic apoptotic signaling pathway|
|cellular response to light stimulus|
|histone binding|
|negative regulation of chromosome organization|
|chromatin assembly|
|response to UV|
|regulation of histone modification|
|chromatin assembly or disassembly|
|regulation of intrinsic apoptotic signaling pathway|
|cellular response to radiation|
|DNA packaging|
|regulation of signal transduction by p53 class mediator|
|regulation of chromatin organization|
|negative regulation of apoptotic signaling pathway|
|transcription corepressor activity|
|DNA conformation change|
|ribosome biogenesis|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|response to radiation|
|ribonucleoprotein complex biogenesis|
|negative regulation of intracellular signal transduction|
|negative regulation of protein modification process|
|chromatin organization|
|negative regulation of cellular component organization|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.05|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.71|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOC2L Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>