NOD2 [The Human Chemical-Genetic Interaction Map Project]

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======= NOD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOD2
  * **<color #00a2e8>Official Name</color>**: nucleotide binding oligomerization domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64127|64127]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC29|Q9HC29]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605956|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). {ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:19701189, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:28436939}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NACHT|
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of muramyl dipeptide|
|muramyl dipeptide binding|
|detection of peptidoglycan|
|regulation of prostaglandin-E synthase activity|
|positive regulation of protein K63-linked ubiquitination|
|regulation of prostaglandin-endoperoxide synthase activity|
|positive regulation of prostaglandin-endoperoxide synthase activity|
|positive regulation of prostaglandin-E synthase activity|
|cytokine secretion involved in immune response|
|cellular response to peptidoglycan|
|positive regulation of gamma-delta T cell activation|
|negative regulation of macrophage apoptotic process|
|positive regulation of dendritic cell cytokine production|
|regulation of gamma-delta T cell activation|
|positive regulation of dendritic cell antigen processing and presentation|
|nucleotide-binding oligomerization domain containing 2 signaling pathway|
|positive regulation of antigen processing and presentation|
|cellular response to muramyl dipeptide|
|positive regulation of isomerase activity|
|regulation of isomerase activity|
|regulation of protein K63-linked ubiquitination|
|regulation of macrophage apoptotic process|
|response to peptidoglycan|
|regulation of dendritic cell cytokine production|
|regulation of dendritic cell antigen processing and presentation|
|detection of molecule of bacterial origin|
|positive regulation of protein polyubiquitination|
|detection of bacterium|
|detection of other organism|
|positive regulation of nitric-oxide synthase biosynthetic process|
|CARD domain binding|
|negative regulation of myeloid cell apoptotic process|
|positive regulation of type 2 immune response|
|peptidoglycan binding|
|positive regulation of interleukin-17 production|
|positive regulation of cytokine production involved in inflammatory response|
|detection of external biotic stimulus|
|maintenance of gastrointestinal epithelium|
|regulation of nitric-oxide synthase biosynthetic process|
|regulation of antigen processing and presentation|
|response to muramyl dipeptide|
|cytokine production involved in immune response|
|regulation of protein polyubiquitination|
|detection of biotic stimulus|
|epithelial structure maintenance|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|regulation of myeloid cell apoptotic process|
|regulation of interleukin-17 production|
|regulation of type 2 immune response|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of interleukin-1 beta secretion|
|cytoplasmic pattern recognition receptor signaling pathway|
|positive regulation of lipid kinase activity|
|positive regulation of interleukin-10 production|
|positive regulation of interleukin-1 secretion|
|regulation of cytokine production involved in inflammatory response|
|Hsp90 protein binding|
|Hsp70 protein binding|
|negative regulation of leukocyte apoptotic process|
|regulation of interleukin-1 beta secretion|
|cytokine secretion|
|positive regulation of phospholipid metabolic process|
|positive regulation of interleukin-8 production|
|positive regulation of interleukin-1 beta production|
|positive regulation of Notch signaling pathway|
|regulation of interleukin-10 production|
|positive regulation of oxidoreductase activity|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of interleukin-1 secretion|
|positive regulation of cytokine production involved in immune response|
|positive regulation of interleukin-1 production|
|regulation of lipid kinase activity|
|regulation of interleukin-8 production|
|digestive system process|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of interleukin-1 beta production|
|JNK cascade|
|regulation of leukocyte apoptotic process|
|regulation of cytokine production involved in immune response|
|regulation of phospholipid metabolic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|interleukin-1-mediated signaling pathway|
|regulation of oxidoreductase activity|
|positive regulation of production of molecular mediator of immune response|
|regulation of Notch signaling pathway|
|stress-activated MAPK cascade|
|regulation of NIK/NF-kappaB signaling|
|digestion|
|positive regulation of protein ubiquitination|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte mediated immunity|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cytokine secretion|
|positive regulation of JNK cascade|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|stress-activated protein kinase signaling cascade|
|positive regulation of lipid metabolic process|
|vesicle|
|regulation of tumor necrosis factor production|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|intracellular receptor signaling pathway|
|protein localization to extracellular region|
|positive regulation of B cell activation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|peptide secretion|
|cellular response to interleukin-1|
|production of molecular mediator of immune response|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|cellular response to molecule of bacterial origin|
|basolateral plasma membrane|
|response to interleukin-1|
|regulation of protein ubiquitination|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to biotic stimulus|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|protein-containing complex binding|
|actin binding|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|cellular response to peptide|
|activation of protein kinase activity|
|defense response to bacterium|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|enzyme binding|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|cytoskeleton|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|cellular response to drug|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|regulation of peptide secretion|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|cellular response to lipid|
|detection of chemical stimulus|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|activation of immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|defense response to other organism|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3821
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOD2 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>