NOM1 [The Human Chemical-Genetic Interaction Map Project]

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======= NOM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOM1
  * **<color #00a2e8>Official Name</color>**: nucleolar protein with MIF4G domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64434|64434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5C9Z4|Q5C9Z4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611269|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MA3|
|MIF4G|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hair follicle maturation|
|ribosomal small subunit biogenesis|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|molting cycle|
|hair cycle|
|anatomical structure maturation|
|developmental maturation|
|ribosome biogenesis|
|skin development|
|epidermis development|
|ribonucleoprotein complex biogenesis|
|nucleolus|
|epithelium development|
|RNA binding|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.91|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.46|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.88|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.79|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.73|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.84|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.95|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 79/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|5/28|
|bone|2/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|2/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1364
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOM1 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>