NOP2 [The Human Chemical-Genetic Interaction Map Project]

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======= NOP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP2
  * **<color #00a2e8>Official Name</color>**: NOP2 nucleolar protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4839|4839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46087|P46087]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164031|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). {ECO:0000269|PubMed:24120868, ECO:0000305, ECO:0000305|PubMed:23913415}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P120R|
|Nol1 Nop2 Fmu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (cytosine-C5-)-methyltransferase activity|
|rRNA base methylation|
|rRNA methylation|
|ribosomal large subunit assembly|
|rRNA modification|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|RNA methylation|
|RNA modification|
|regulation of signal transduction by p53 class mediator|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|positive regulation of cell population proliferation|
|RNA binding|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.72|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.74|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.77|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.78|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.81|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.88|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.94|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.95|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.07|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.1|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.13|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.27|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.28|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.48|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.56|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.64|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.69|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 688/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/28|
|bone|22/26|
|breast|29/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|19/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 199
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOP2 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>