NOP56 [The Human Chemical-Genetic Interaction Map Project]

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======= NOP56 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP56
  * **<color #00a2e8>Official Name</color>**: NOP56 ribonucleoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10528|10528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00567|O00567]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOP56&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOP56|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614154|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOP5NT|
|NOSIC|
|Nop|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone methyltransferase binding|
|box C/D snoRNP complex|
|pre-snoRNP complex|
|small nucleolar ribonucleoprotein complex|
|snoRNA binding|
|small-subunit processome|
|fibrillar center|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|cadherin binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.9|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.606|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.513|
|[[:human genes:g:gar1|GAR1]]|0.427|
|[[:human genes:s:supt5h|SUPT5H]]|0.426|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.422|
|[[:human genes:c:chd4|CHD4]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.415|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.413|
|[[:human genes:t:twistnb|TWISTNB]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 693/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|23/28|
|bone|26/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|21/21|
|liver|18/20|
|lung|68/75|
|lymphocyte|14/16|
|ovary|23/26|
|pancreas|20/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1508
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOP56 Expression in NALM6 Cells: 9.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>