NPFF [The Human Chemical-Genetic Interaction Map Project]

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======= NPFF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPFF
  * **<color #00a2e8>Official Name</color>**: neuropeptide FF-amide peptide precursor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8620|8620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15130|O15130]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPFF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPFF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. {ECO:0000269|PubMed:11587714}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somatostatin secretion|
|vasopressin secretion|
|acute inflammatory response to antigenic stimulus|
|negative regulation of heart rate|
|negative regulation of response to food|
|negative regulation of appetite|
|negative regulation of response to nutrient levels|
|negative regulation of response to extracellular stimulus|
|regulation of response to food|
|regulation of appetite|
|inflammatory response to antigenic stimulus|
|negative regulation of heart contraction|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|neuropeptide hormone activity|
|response to morphine|
|response to isoquinoline alkaloid|
|negative regulation of blood circulation|
|positive regulation of blood pressure|
|negative regulation of insulin secretion|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|regulation of membrane depolarization|
|negative regulation of peptide hormone secretion|
|axon terminus|
|peptide hormone secretion|
|negative regulation of hormone secretion|
|excitatory postsynaptic potential|
|maternal process involved in female pregnancy|
|G protein-coupled receptor binding|
|chemical synaptic transmission, postsynaptic|
|acute inflammatory response|
|hormone secretion|
|response to anesthetic|
|hormone transport|
|postsynapse|
|regulation of heart rate|
|regulation of postsynaptic membrane potential|
|neuropeptide signaling pathway|
|spinal cord development|
|response to alkaloid|
|negative regulation of protein secretion|
|perikaryon|
|regulation of nervous system process|
|negative regulation of peptide secretion|
|vesicle|
|signal release|
|peptide secretion|
|regulation of insulin secretion|
|female pregnancy|
|regulation of blood pressure|
|negative regulation of protein transport|
|response to ammonium ion|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|negative regulation of secretion|
|regulation of heart contraction|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|response to xenobiotic stimulus|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|negative regulation of response to external stimulus|
|blood circulation|
|circulatory system process|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to nutrient levels|
|inflammatory response|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|cellular homeostasis|
|response to organic cyclic compound|
|central nervous system development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|regulation of protein localization|
|export from cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|peptide transport|
|amide transport|
|extracellular space|
|negative regulation of response to stimulus|
|homeostatic process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPFF Expression in NALM6 Cells: -1.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>