NPIPA7 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPA7
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member A7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=101059938|101059938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/E9PJI5|E9PJI5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.17|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.15|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.85|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.84|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.83|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.81|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.466|
|[[:human genes:f:fam25b|FAM25B]]|0.461|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.433|
|[[:human genes:o:orc1|ORC1]]|0.422|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.422|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.417|
|[[:human genes:r:rrp7a|RRP7A]]|0.41|
|[[:human genes:u:uqcrh|UQCRH]]|0.402|
|[[:human genes:p:prim1|PRIM1]]|0.4|
|[[:human genes:f:fam25g|FAM25G]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2092
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPA7 Expression in NALM6 Cells: 3.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>