NPIPA8 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPA8
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member A8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=101059953|101059953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DM63|P0DM63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.16|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.13|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.82|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.8|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.467|
|[[:human genes:f:fam25b|FAM25B]]|0.461|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.433|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.423|
|[[:human genes:o:orc1|ORC1]]|0.422|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.417|
|[[:human genes:r:rrp7a|RRP7A]]|0.409|
|[[:human genes:u:uqcrh|UQCRH]]|0.402|
|[[:human genes:f:fam25g|FAM25G]]|0.401|
|[[:human genes:p:prim1|PRIM1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2093
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPA8 Expression in NALM6 Cells: 2.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>