NPIPB3 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPB3
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23117|23117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92617|Q92617]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.1|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.02|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.96|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.95|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.73|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.75|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.8|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.8|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.8|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.81|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.84|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.88|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.95|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.96|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.97|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.02|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.05|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.05|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.08|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.14|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.17|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.44|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.44|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.46|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.48|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.52|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.61|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.66|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.77|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.7|
|[[:human genes:s:snrpa1|SNRPA1]]|0.457|
|[[:human genes:r:rps9|RPS9]]|0.429|
|[[:human genes:p:plekha4|PLEKHA4]]|0.422|
|[[:human genes:c:copb1|COPB1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPB3 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>