NPR2 [The Human Chemical-Genetic Interaction Map Project]

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======= NPR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPR2
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4882|4882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20594|P20594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Guanylate cyc|
|ANF receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|natriuretic peptide receptor activity|
|negative regulation of oocyte maturation|
|negative regulation of oocyte development|
|negative regulation of oogenesis|
|peptide receptor activity|
|positive regulation of cGMP-mediated signaling|
|regulation of oocyte maturation|
|negative regulation of cell maturation|
|guanylate cyclase activity|
|response to granulocyte macrophage colony-stimulating factor|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|receptor guanylyl cyclase signaling pathway|
|regulation of oocyte development|
|regulation of oogenesis|
|cGMP biosynthetic process|
|hormone binding|
|regulation of cGMP-mediated signaling|
|negative regulation of meiotic cell cycle|
|cGMP metabolic process|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|regulation of cell maturation|
|cGMP-mediated signaling|
|peptide hormone binding|
|cyclic nucleotide metabolic process|
|regulation of meiotic cell cycle|
|negative regulation of reproductive process|
|regulation of cardiac conduction|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of reproductive process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|bone development|
|negative regulation of multi-organism process|
|protein kinase activity|
|regulation of heart contraction|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ossification|
|regulation of blood circulation|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|negative regulation of cell development|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|GTP binding|
|blood circulation|
|circulatory system process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|skeletal system development|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell cycle|
|regulation of system process|
|carbohydrate derivative biosynthetic process|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of multi-organism process|
|organophosphate metabolic process|
|regulation of cell development|
|negative regulation of developmental process|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|small molecule metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12323
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPR2 Expression in NALM6 Cells: 0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>