NPR3 [The Human Chemical-Genetic Interaction Map Project]

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======= NPR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPR3
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4883|4883]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17342|P17342]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. {ECO:0000250|UniProtKB:P70180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANF receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|natriuretic peptide receptor activity|
|osteoclast proliferation|
|pancreatic juice secretion|
|hormone binding|
|chloride ion binding|
|positive regulation of urine volume|
|negative regulation of adenylate cyclase activity|
|negative regulation of cyclase activity|
|secretion by tissue|
|positive regulation of nitric-oxide synthase activity|
|regulation of urine volume|
|negative regulation of lyase activity|
|regulation of osteoblast proliferation|
|positive regulation of monooxygenase activity|
|regulation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|regulation of cyclase activity|
|regulation of nitric-oxide synthase activity|
|regulation of lyase activity|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of cold-induced thermogenesis|
|peptide binding|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|phosphatidylinositol-mediated signaling|
|digestive system process|
|body fluid secretion|
|inositol lipid-mediated signaling|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of oxidoreductase activity|
|leukocyte proliferation|
|renal system process|
|digestion|
|regulation of smooth muscle cell proliferation|
|regulation of cold-induced thermogenesis|
|regulation of blood pressure|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|blood circulation|
|circulatory system process|
|skeletal system development|
|regulation of body fluid levels|
|cell population proliferation|
|protein-containing complex|
|negative regulation of cell population proliferation|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of cell population proliferation|
|intracellular signal transduction|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPR3 Expression in NALM6 Cells: -1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>