NR4A1 [The Human Chemical-Genetic Interaction Map Project]

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======= NR4A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR4A1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 4 group A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3164|3164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22736|P22736]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR4A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR4A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. {ECO:0000250, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to corticotropin-releasing hormone|
|cellular response to corticotropin-releasing hormone stimulus|
|endothelial cell chemotaxis|
|regulation of type B pancreatic cell proliferation|
|glucocorticoid receptor binding|
|cell migration involved in sprouting angiogenesis|
|blood vessel endothelial cell migration|
|cellular response to vascular endothelial growth factor stimulus|
|nuclear receptor activity|
|steroid hormone receptor activity|
|sprouting angiogenesis|
|endothelial cell migration|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|positive regulation of endothelial cell proliferation|
|fat cell differentiation|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|steroid hormone mediated signaling pathway|
|regulation of endothelial cell proliferation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|ameboidal-type cell migration|
|transcription initiation from RNA polymerase II promoter|
|cellular response to steroid hormone stimulus|
|positive regulation of epithelial cell proliferation|
|transcription factor complex|
|cell chemotaxis|
|DNA-templated transcription, initiation|
|nuclear membrane|
|cellular response to peptide hormone stimulus|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|cellular response to peptide|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|response to peptide hormone|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to peptide|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|response to growth factor|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|cellular response to nitrogen compound|
|zinc ion binding|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell migration|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|locomotion|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.01|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.99|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.73|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.75|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR4A1 Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>