NRBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= NRBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRBP1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29959|29959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHY1|Q9UHY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endomembrane system|
|cell cortex|
|transcription initiation from RNA polymerase II promoter|
|lamellipodium|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|DNA-templated transcription, initiation|
|protein serine/threonine kinase activity|
|Golgi vesicle transport|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein homodimerization activity|
|protein phosphorylation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ATP binding|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.71|
|[[:results:exp303|39°C R06 exp303]]|1.7|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.7|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.85|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.96|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.03|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.1|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.19|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.26|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.4|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 413/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|15/28|
|bone|13/26|
|breast|18/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|8/21|
|liver|12/20|
|lung|37/75|
|lymphocyte|9/16|
|ovary|10/26|
|pancreas|19/24|
|peripheral nervous system|7/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|23/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRBP1 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>