NRXN1 [The Human Chemical-Genetic Interaction Map Project]

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======= NRXN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRXN1
  * **<color #00a2e8>Official Name</color>**: neurexin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9378|9378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P58400|Q9ULB1"|"P58400|Q9ULB1"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRXN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRXN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600565|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gephyrin clustering involved in postsynaptic density assembly|
|neuroligin clustering involved in postsynaptic membrane assembly|
|neuroligin family protein binding|
|regulation of grooming behavior|
|trans-synaptic signaling by endocannabinoid|
|trans-synaptic signaling by lipid|
|postsynaptic density protein 95 clustering|
|postsynaptic density assembly|
|imitative learning|
|vocal learning|
|observational learning|
|postsynaptic specialization assembly|
|positive regulation of synapse maturation|
|learned vocalization behavior or vocal learning|
|regulation of postsynaptic density assembly|
|regulation of postsynapse assembly|
|postsynaptic membrane assembly|
|regulation of postsynaptic specialization assembly|
|auditory behavior|
|regulation of synapse maturation|
|acetylcholine receptor binding|
|excitatory synapse assembly|
|regulation of excitatory synapse assembly|
|integral component of presynaptic active zone membrane|
|mechanosensory behavior|
|regulation of postsynaptic density organization|
|prepulse inhibition|
|neuron cell-cell adhesion|
|postsynaptic density organization|
|vocalization behavior|
|postsynaptic specialization organization|
|postsynapse assembly|
|synaptic membrane adhesion|
|response to auditory stimulus|
|startle response|
|positive regulation of excitatory postsynaptic potential|
|postsynaptic membrane organization|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|positive regulation of synaptic transmission, glutamatergic|
|membrane assembly|
|calcium channel regulator activity|
|membrane biogenesis|
|modulation of excitatory postsynaptic potential|
|receptor clustering|
|intraspecies interaction between organisms|
|social behavior|
|neuromuscular process controlling balance|
|cell adhesion molecule binding|
|protein localization to synapse|
|positive regulation of nervous system process|
|positive regulation of synapse assembly|
|multi-organism behavior|
|GABA-ergic synapse|
|regulation of synaptic transmission, glutamatergic|
|regulation of behavior|
|presynaptic membrane|
|Schaffer collateral - CA1 synapse|
|localization within membrane|
|postsynapse organization|
|synapse assembly|
|regulation of postsynapse organization|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of synapse assembly|
|neuromuscular process|
|regulation of synaptic vesicle cycle|
|regulation of nervous system process|
|vesicle|
|adult behavior|
|learning|
|positive regulation of synaptic transmission|
|signal release|
|neurotransmitter transport|
|signaling receptor activity|
|response to mechanical stimulus|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|nuclear membrane|
|learning or memory|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse organization|
|cognition|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|neuronal cell body|
|axonogenesis|
|axon development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of system process|
|protein-containing complex|
|cell surface|
|neuron projection development|
|calcium ion binding|
|cell morphogenesis|
|organelle assembly|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|nucleolus|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|secretion by cell|
|endoplasmic reticulum|
|neuron differentiation|
|export from cell|
|regulation of response to external stimulus|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.88|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRXN1 Expression in NALM6 Cells: 1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>