NSDHL [The Human Chemical-Genetic Interaction Map Project]

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======= NSDHL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSDHL
  * **<color #00a2e8>Official Name</color>**: N/AD(P) dependent steroid dehydrogenase-like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50814|50814]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15738|Q15738]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSDHL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSDHL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000269|PubMed:14506130}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|3Beta HSD|
|RmlD sub bind|
|Polysacc synt 2|
|NAD binding 4|
|Epimerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|
|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity|
|4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity|
|4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity|
|3-beta-hydroxy-delta5-steroid dehydrogenase activity|
|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|
|labyrinthine layer blood vessel development|
|placenta blood vessel development|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|labyrinthine layer development|
|sterol biosynthetic process|
|hair follicle development|
|smoothened signaling pathway|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|lipid droplet|
|embryonic placenta development|
|molting cycle|
|hair cycle|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|oxidoreductase activity|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|placenta development|
|organic hydroxy compound biosynthetic process|
|steroid metabolic process|
|alcohol metabolic process|
|in utero embryonic development|
|skin development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|circulatory system development|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|embryo development|
|endoplasmic reticulum|
|epithelium development|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.05|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.89|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.78|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.78|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14501
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSDHL Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>